Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung.
Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung.
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DOI：
10.1016/0163-7258(90)90065-a
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发表时间：
1990
影响因子：
13.5
通讯作者：
J. Baron;J. Voigt
中科院分区：
文献类型：
--
作者：
J. Baron;J. Voigt
尽管某些肺细胞比其他细胞更容易受损，但肺内异生物质的代谢通常会导致毒性。这种不同的敏感性可能是由于细胞特异性的异生素激活和解毒差异造成的。外源代谢酶（细胞色素 P-450、NADPH-细胞色素 P-450 还原酶、环氧化物水解酶、谷胱甘肽 S 转移酶、UDP-葡萄糖醛酸基转移酶和磺基转移酶）和芳基烃（苯并[a]芘）羟化酶活性的定位和分布 讨论了肺内分别通过免疫组织化学和组织化学测定的情况。研究结果表明，异生物质可以通过支气管上皮细胞、Clara 和纤毛细支气管上皮细胞、II 型肺细胞和其他肺泡壁细胞进行原位代谢，尽管程度不同，并且这些细胞之间不一定均匀诱导酶和活性。
The metabolism of xenobiotics within lung often leads to toxicity, although certain pulmonary cells are more readily damaged than others. This differential susceptibility can result from cell-specific differences in xenobiotic activation and detoxication. The localization and distribution of xenobiotic-metabolizing enzymes (cytochromes P-450, NADPH-cytochrome P-450 reductase, epoxide hydrolase, glutathioneS-transferases, UDP-glucuronosyltransferases, and a sulfotransferase) and of aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity determined immunohistochemically and histochemically, respectively, within lung are discussed. Findings reveal that xenobiotics can be metabolizedin situ, albeit to different extents, by bronchial epithelial cells, Clara and ciliated bronchiolar epithelial cells, and type II pneumocytes and other alveolar wall cells and that enzymes and activities are not necessarily induced uniformly among these cells.