Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats
Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats
复制标题
DOI：
10.1128/aac.46.7.2287-2291.2002
复制
发表时间：
2002-07-01
影响因子：
4.9
通讯作者：
Lipkin, WI
中科院分区：
文献类型：
--
作者：
Solbrig, MV;Schlaberg, R;Lipkin, WI
在博尔纳病大鼠模型中，脑内注射利巴韦林可在不改变病毒滴度或核酸的情况下导致临床改善。尽管大脑中编码白介素1β(IL-1β)、IL-10和伽马干扰素的mRNAs增加，但小胶质细胞和浸润性CD4和CD8细胞的水平下降。脑内注射利巴韦林可能通过影响小胶质细胞的增殖来降低发病率。
In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1beta (IL-1beta), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell proliferation.