INVOLUTION AND THE ETIOLOGY OF BREAST-CANCER
INVOLUTION AND THE ETIOLOGY OF BREAST-CANCER
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DOI：
10.1002/cncr.2820741330
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发表时间：
1994-07-01
期刊：
影响因子：
6.2
通讯作者：
TARONE, RE
中科院分区：
文献类型：
--
作者：
HENSON, DE;TARONE, RE
由于衰老与癌症发展之间的关系已得到公认，作者提出，退化的速度和程度可能是乳腺癌病因学的重要因素。他们进一步检查了现有的流行病学和组织病理学数据，以评估异常复旧与乳腺癌风险之间可能的关联。这种关联的证据在很大程度上是间接的，因为研究并没有专门设计来评估复旧过程与乳腺癌之间的关系。在进行组织病理学比较乳腺癌患者和年龄匹配对照的复旧程度之前，复旧在乳腺癌病因学中的作用仍不确定。
Because of the recognized relationship between aging and the development of cancer, the authors have proposed that the rate and extent of involution may be important factors in the etiology of breast cancer. They further have examined existing epidemiologic and histopathologic data to evaluate the possible association between abnormal involution and breast cancer risk. Evidence for the association is largely circumstantial, because studies have not been designed specifically to evaluate the relationship between the process of involution and breast cancer. Until studies are performed to compare histopathologically the extent of involution in breast cancer patients and age-matched controls, the role of involution in the etiology of breast cancer will remain uncertain.