Relation of plasma homocysteine to plasma amyloid beta levels
Relation of plasma homocysteine to plasma amyloid beta levels
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DOI：
10.1007/s11064-006-9207-7
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发表时间：
2007-04-01
影响因子：
4.4
通讯作者：
Mayeux, Richard
中科院分区：
文献类型：
--
作者：
Luchsinger, Jose A.;Tang, Ming-Xin;Mayeux, Richard
背景：血浆同型半胱氨酸和β淀粉样蛋白（A β）升高与阿尔茨海默病（AD）有关。我们调查了这些生物标志物之间的横截面关联。方法：我们使用线性回归将血浆同型半胱氨酸和A β相关，调整年龄，性别，肌酐，APOE-β 4和种族，在327名78 +/- 6.6岁的人中进行。结果：血浆同型半胱氨酸与年龄、血清肌酐、血浆A β 40和A β 42相关，与血清维生素B12和叶酸呈负相关。A β 42，而不是A β 40，与痴呆症的后期发展有关。同型半胱氨酸与较高的A β 40水平相关（系数= 2.0; P < 0.0001），调整肌酐后，这种关联减弱（系数= 1.0; P < 0.0001）。同型半胱氨酸和A β 42之间的粗关联较弱（系数= 0.5; P = 0.01），在调整肌酐后变得不显著（系数= 0.4; P = 0.06）。这些关联与种族、APOE-β 4的存在或痴呆无关。同型半胱氨酸的四分位数分析表明，这些协会主要是由第四个四分位数。结论：血浆同型半胱氨酸是直接相关的A β 40。与A β 42的关联并不显著。这些结果似乎表明，同型半胱氨酸与衰老有关，但不是专门与AD。
Background: Elevated plasma homocysteine and amyloid beta (A beta) have been associated with Alzheimer's disease (AD). We investigated the cross-sectional association between these biomarkers.Methods: We used linear regression to relate plasma homocysteine and A beta adjusting for age, gender, creatinine, APOE-epsilon 4, and ethnic group in 327 persons aged 78 +/- 6.6 years.Results: Plasma homocysteine correlated with age, serum creatinine, plasma A beta 40 and A beta 42, and was inversely correlated with serum vitamin B12, and folate. A beta 42, but not A beta 40, was related to later development of dementia. Homocysteine was related to higher A beta 40 levels (coefficient = 2.0; P < 0.0001) and this association was attenuated after adjustment for creatinine (coefficient = 1.0; P < 0.0001). The crude association between homocysteine and A beta 42 was weaker (coefficient = 0.5; P = 0.01) and became non-significant after adjustment for creatinine (coefficient = 0.4; P = 0.06). These associations were unrelated to ethnicity, the presence of APOE-epsilon 4 or dementia. Analyses by quartiles of homocysteine showed that these association were driven primarily by the fourth quartile.Conclusions: Plasma homocysteine is directly related to A beta 40. The association with A beta 42 is not significant. These results seem to indicate that homocysteine is related to aging but not specifically to AD.