Neutrophils recruitment during sepsis: Critical points and crossroads
Neutrophils recruitment during sepsis: Critical points and crossroads
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DOI：
10.2741/3542
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发表时间：
2009-01-01
影响因子：
3.1
通讯作者：
Soriano, Francisco Garcia
中科院分区：
文献类型：
--
作者：
da Silva, Fabiano Pinheiro;Soriano, Francisco Garcia
启动对细菌感染的炎性全身反应的机制导致高死亡率，并构成重症监护病房（ICU）中死亡的第一原因。脓毒症是一种知之甚少的疾病，尽管生命支持技术和抗生素的管理，没有更多的可以做，以改善其诊断和治疗。本文的主要目的是讨论中性粒细胞募集在脓毒症中的作用，剖析这一复杂过程中所涉及的分子机制及其对这一突出死亡原因的发病机制的重要性。
The mechanisms that initiate an inflammatory systemic response to a bacterial infection lead to a high mortality and constitute the first cause of death in Critical Care Units (ICU's). Sepsis is a poorly understood disease and despite life support techniques and the administration of antibiotics, not much more can be done to improve its diagnosis and treatment. The present article has as main objective to discuss the role of neutrophils recruitment in sepsis, dissecting the molecular mechanisms implicated in this complex process and its importance to the pathogenesis of this outstanding cause of death.