Multivesicular release and saturation of glutamatergic signalling at retinal ribbon synapses.

Multivesicular release and saturation of glutamatergic signalling at retinal ribbon synapses.
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视网膜带状突触谷氨酸信号的多囊泡释放和饱和。

DOI:
10.1113/jphysiol.2006.125302
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发表时间:
2007
期刊:
The Journal of physiology
影响因子:
--
通讯作者:
Singer,JoshuaH
Singer,JoshuaH
中科院分区:
--
文献类型:
--
作者:
Singer,JoshuaH

文献摘要

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Pronounced multivesicular release (MVR) occurs at the ribbon synapses of sensory neurones that signal via graded potential changes. As MVR increases the likelihood of postsynaptic receptor saturation, it is of interest to consider how sensory synapses overcome this problem and use MVR to encode signals of widely varying intensities. Here, I discuss three postsynaptic mechanisms that permit three different retinal synapses to utilize MVR.