Racial and temporal variations in the prevalence of heart defects
Racial and temporal variations in the prevalence of heart defects
复制标题
DOI：
10.1542/peds.107.3.e32
复制
发表时间：
2001-03-01
期刊：
影响因子：
8
通讯作者：
Erickson, JD
中科院分区：
文献类型：
--
作者：
Botto, LD;Correa, A;Erickson, JD
背景。记录先天性心脏缺陷的患病率和趋势为儿科实践、保健计划和因果研究提供了有用的数据。然而，大多数基于人口的研究使用的是20世纪70年代和80年代的数据。近年来，我们试图在一个明确定义的人群中扩展心脏缺陷发生的时间和种族差异的研究。我们使用的数据来自亚特兰大大都会先天性缺陷计划，这是一个基于人群的登记，从多个来源积极确定病例。心脏缺陷在1岁以下的活产婴儿、死产婴儿和居住在亚特兰大大都市的终止妊娠的母亲中被发现。从1968年到1997年，该登记处在937195名婴儿中确定了5813例主要先天性心脏缺陷，患病率为6.2‰。1995年至1997年，患病率增加到每1000名新生儿中有9.0例。室间隔缺损、法洛四联症、房室间隔缺损和肺动脉狭窄的患病率增加，而大动脉转位的患病率下降。对于某些缺陷，患病率和趋势因种族而异。先天性心脏缺陷的发病率正在上升。虽然大多数发现可能是由于改善了病例确定和报告，但其他发现可能是由于人群中危险因素分布的变化。人们对种族差异的基础还不完全了解。
Background. Documenting the prevalence and trends of congenital heart defects provides useful data for pediatric practice, health-care planning, and causal research. Yet, most population-based studies use data from the 1970s and 1980s. We sought to extend into more recent years the study of temporal and racial variations of heart defects occurrence in a well-defined population.Methods. We used data from the Metropolitan Atlanta Congenital Defects Program, a population-based registry with active case ascertainment from multiple sources. Heart defects were identified among liveborn infants up to 1 year old, among stillborn infants, and among pregnancy terminations to mothers residing in metropolitan Atlanta.Results. From 1968 through 1997, the registry ascertained 5813 major congenital heart defects among 937 195 infants, for a prevalence of 6.2 per 1000. The prevalence increased to 9.0 per 1000 births in 1995 through 1997. The prevalence of ventricular septal defects, tetralogy of Fallot, atrioventricular septal defects, and pulmonary stenosis increased, whereas that of transposition of the great arteries decreased. For some defects, prevalence and trends varied by race.Conclusions. The prevalence of congenital heart defects is increasing. Whereas most findings likely result from improved case ascertainment and reporting, others might be because of changes in the distribution of risk factors in the population. The basis of the racial variations is incompletely understood.