Effects of four different regimens of hormone replacement therapy on hemostatic parameters: a prospective randomized study.
Effects of four different regimens of hormone replacement therapy on hemostatic parameters: a prospective randomized study.
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四种不同的激素替代疗法对止血参数的影响：一项前瞻性随机研究。
DOI：
10.1016/j.maturitas.2005.05.010
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发表时间：
2006
期刊：
影响因子：
4.9
通讯作者：
O. Himmetoğlu
中科院分区：
文献类型：
--
作者：
M. Taner;Erdinc Ozpolat;Ç. Taşkıran;M. Onan;T. Gursel;E. Karabulut;R. Gursoy;O. Himmetoğlu
OBJECTIVETo compare the effects of four different regimens including oral and transdermal formulations with or without progestins on the hemostatic system in a prospective randomized fashion.METHODSEighty-eight women were randomized to four groups receiving continuous transdermal estradiol 50μg/day (tE2), oral conjugated equine estrogen 0.625mg/day (CEE 0.625mg), oral conjugated equine estrogen 0.625mg/day plus medroxyprogesterone acetate 2.5mg/day (CEE 0.625mg/MPA 2.5mg), or oral 2mg 17-β estradiol combined with 1mg norethistrone acetate (E2/norethistrone). The hysterectomized patients received only estrogen, and the remaining women received the estrogen plus progesterone combination regimens. As a marker of hemostatic system fibrinogen, tissue plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) levels were measured initially, and after 1 and 6 months of therapy.RESULTSThe treatment groups were well matched for baseline characteristics including age, height, weight, body mass index, and systolic and diastolic blood pressures. During the study period fibrinogen levels were below the baseline values in all groups. However, the decrease was only statistically significant in patients treated with oral 0.625mg/day CEE. tPA levels were decreased significantly by tE2, CEE 0.625mg, and CEE 0.625mg/MPA 2.5mg. PAI-1 levels were decreased significantly by CEE 0.625mg, and CEE 0.625mg/MPA 2.5mg. When the effects of the four different regimens were compared using percentage changes from the baseline, no significant difference was found among the treatment groups.CONCLUSIONone of the treatment regimens resulted in a more coagulable state. Oral therapy with CEE decreased the levels of all parameters, and MPA did not impair this beneficial effect, except for in fibrinogen. Transdermal therapy had a minimal effect. No significant difference was noted among the four regimens.
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中年女性血浆纤维蛋白原的分布及其相关性。
DOI：
10.1161/01.atv.15.12.2085
发表时间：
1995
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Stefanick,ML;Legault,C;Tracy,RP;Howard,G;Kessler,CM;Lucas,DL;Bush,TL
通讯作者：
Bush,TL
DOI：
10.1161/01.atv.17.10.2167
发表时间：
1997-10-01
影响因子：
8.7
作者：
Tracy, RP;Psaty, BM;Kuller, LH
通讯作者：
Kuller, LH
影响因子：
158.5
作者：
Grodstein, F;Stampfer, MJ;Speizer, FE
通讯作者：
Speizer, FE
DOI：
10.1001/jama.1987.03400090067035
发表时间：
1987-09
期刊：
JAMA
影响因子：
--
作者：
W. Kannel;P. Wolf;W. Castelli;R. D'Agostino
通讯作者：
W. Kannel;P. Wolf;W. Castelli;R. D'Agostino
无对抗雌激素替代疗法对绝经后妇女凝血和炎症标志物影响的前瞻性随机研究。
DOI：
10.1210/jcem.86.8.7768
发表时间：
2001
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Luyer,MD;Khosla,S;Owen,WG;Miller,VM
通讯作者：
Miller,VM