Rapid clearance of Lyme disease spirochetes lacking OspC from skin
Rapid clearance of Lyme disease spirochetes lacking OspC from skin
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DOI：
10.1128/iai.01725-06
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发表时间：
2007-03-01
影响因子：
3.1
通讯作者：
Rosa, Patricia
中科院分区：
文献类型：
--
作者：
Tilly, Kit;Bestor, Aaron;Rosa, Patricia
我们以前证明，伯氏疏螺旋体需要OspC定殖哺乳动物宿主。为了描述这一要求，我们分析了ospC突变螺旋体的清除，发现它们在48小时内被消除。我们得出结论，B.伯氏菌在传播后立即使用OspC来抵抗宿主的先天防御。
We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.