Fluorine-19 MRI Contrast Agents for Cell Tracking and Lung Imaging
Fluorine-19 MRI Contrast Agents for Cell Tracking and Lung Imaging
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DOI：
10.4137/mri.s23559
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Foster, Paula J.
中科院分区：
文献类型：
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作者：
Fox, Matthew S.;Gaudet, Jeffrey M.;Foster, Paula J.
以氟-19 （F-19）为基础的磁共振成像造影剂将在若干医疗干预领域彻底改变基于成像的研究和临床试验。首先，它们用于表征体内细胞行为可能有助于使细胞治疗更接近临床接受。其次，它们在肺部成像中的应用提供了一种新颖的、无创的对通气空间的检查，而不需要复杂的、难以分配的硬件。本文回顾了基于f -19的细胞跟踪和使用磁共振成像的肺部成像的现状，并描述了这些领域的方法之间的联系，以及它们如何从成像含f -19化合物时遇到的共同问题的解决方案中相互受益，以及硬件和软件的进步。
Fluorine-19 (F-19)-based contrast agents for magnetic resonance imaging stand to revolutionize imaging-based research and clinical trials in several fields of medical intervention. First, their use in characterizing in vivo cell behavior may help bring cellular therapy closer to clinical acceptance. Second, their use in lung imaging provides novel noninvasive interrogation of the ventilated airspaces without the need for complicated, hard-to-distribute hardware. This article reviews the current state of F-19-based cell tracking and lung imaging using magnetic resonance imaging and describes the link between the methods across these fields and how they may mutually benefit from solutions to mutual problems encountered when imaging F-19-containing compounds, as well as hardware and software advancements.