The Plasma S-adenosylmethionine Level is Associated With the Severity of Hepatitis B-Related Liver Disease
The Plasma S-adenosylmethionine Level is Associated With the Severity of Hepatitis B-Related Liver Disease
复制标题
血浆 S-腺苷甲硫氨酸水平与乙型肝炎相关肝病的严重程度相关
DOI：
10.1097/md.0000000000000489
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发表时间：
2015-01-01
期刊：
影响因子：
1.6
通讯作者：
Liu, Quanyan
中科院分区：
文献类型：
--
作者：
Li, Ting;Yu, Guozheng;Liu, Quanyan
慢性肝病患者的蛋氨酸代谢发生改变，包括血浆S-腺苷蛋氨酸（SAMe）水平的变化。本文收集了130例慢性B肝炎（CHB）、肝癌（HCC）患者及正常人的临床资料和血浆SAMe水平。采用单变量和多变量线性回归以及受试者操作特征曲线来确定它们的相关性，血清ALB和PT水平是与CHB和HCC患者血浆SAMe水平相关的独立临床因素。在HCC中观察到比在正常和CHB中更高的SAMe浓度。通过探讨Child-Pugh评分与血浆SAMe水平的相关性，我们发现在CHB和HCC患者中，晚期C期的SAMe水平高于A期。我们进一步评估了SAMe在肝纤维化分期和Child-Pugh分期方面的诊断性能。SAMe预测肝硬化的AUROC为0.721，敏感性和特异性分别为0.707和0.769。血浆SAMe预测Child-Pugh C期的AUROC在CHB患者中为0.706，在HCC患者中为0.825。血清SAMe水平与肝脏疾病严重程度呈正相关，可能是一种潜在的无创性生物标志物。
AbstractAlterations in methionine metabolism that involve changes in the plasma S-adenosylmethionine (SAMe) level occur in chronic liver diseases. However, no evidence is available on whether circulating SAMe is involved in the development of liver cirrhosis and liver cancer.Cross-sectional data on clinical characteristics and plasma SAMe were collected for 130 cases of chronic hepatitis B (CHB) and HCC as well as for normal volunteers. Univariate and multivariate linear regression and receiver operating characteristic curves were introduced to determine their correlations.Serum ALB and PT levels were independent clinical factors that were correlated with the plasma SAMe levels in CHB and HCC patients. A higher SAMe concentration was observed in the HCC than in the normal and CHB. By exploring the association of the Child–Pugh score with the plasma SAMe level, we found a higher SAMe level at advanced Stage C than at stage A in CHB and HCC patients. We further assessed the diagnostic performance of SAMe with respect to the stages of liver fibrosis and Child–Pugh stage. The AUROC of SAMe for the prediction of cirrhosis was 0.721, and the sensitivity and specificity was 0.707 and 0.769, respectively. The AUROC of plasma SAMe to predict Child–Pugh stage C was 0.706 in patients with CHB and 0.825 in HCC patients. The sensitivity was 0.467 and 0.800, respectively; the specificity was 0.904 and 0.781, respectively.The plasma SAMe level was positively correlated with the severity of liver disease and might be a potential noninvasive biomarker.