Novel agents in the treatment of Hodgkin lymphoma: Biological basis and clinical results.
Novel agents in the treatment of Hodgkin lymphoma: Biological basis and clinical results.
复制标题
霍奇金淋巴瘤治疗的新型药物：生物学基础和临床结果。
DOI：
10.1053/j.seminhematol.2016.05.011
复制
发表时间：
2016-07
影响因子：
3.6
通讯作者：
Ansell SM
中科院分区：
文献类型：
--
作者：
Younes A;Ansell SM
何杰金淋巴瘤（HL）是一种B细胞淋巴增生性疾病，通常在联合化疗和放疗或单独化疗时具有良好的预后。然而，复发或有难治性疾病证据的患者的预后很差，疾病进展的患者需要新的治疗方法。HL具有独特的肿瘤微环境，由主要的炎性细胞和少数恶性霍奇金和里德-斯滕伯格（HRS）细胞组成。这种独特的生物学为特异性靶向恶性HRS细胞或靶向炎性肿瘤微环境的新型治疗方法提供了机会。新疗法包括靶向CD 30的抗体药物偶联物、抑制关键细胞信号传导途径的小分子抑制剂、阻断免疫检查点的单克隆抗体或调节免疫微环境的药物，最近都在HL中进行了测试，具有显著的临床活性。目前正在进行多项临床试验，在复发和难治性环境中测试这些药物，但也在治疗的早期阶段，通常与更标准的治疗相结合。
Hodgkin Lymphoma (HL) is a lymphoproliferative disorder of B cells that commonly has a favorable prognosis when treated with either combination chemotherapy and radiation therapy, or chemotherapy alone. However, the prognosis for patients who relapse, or have evidence for refractory disease, is poor and new treatments are needed for patients with progressive disease. HL has a unique tumor microenvironment consisting of a predominance of inflammatory cells and a minority of malignant Hodgkin and Reed-Sternberg (HRS) cells. This unique biology provides an opportunity for novel therapy approaches that either specifically target the malignant HRS cell or target the inflammatory tumor microenvironment. New therapies including antibody drug conjugates targeting CD30, small molecule inhibitors that inhibit critical cell signaling pathways, monoclonal antibodies that block immune checkpoints, or agents that modulate the immune microenvironment have all recently been tested in HL with significant clinical activity. Multiple clinical trials are currently ongoing testing these agents in the relapsed and refractory setting but also in earlier phases of therapy often in combination with more standard treatment.
登录
查看更多内容
影响因子：
12.8
作者：
Ansell, Stephen M.
通讯作者：
Ansell, Stephen M.
影响因子：
45.3
作者：
Younes, Anas;Sureda, Anna;Engert, Andreas
通讯作者：
Engert, Andreas
影响因子：
51.1
作者：
Younes, Anas;Connors, Joseph M.;Ansell, Stephen M.
通讯作者：
Ansell, Stephen M.
影响因子：
158.5
作者：
Younes, Anas;Bartlett, Nancy L.;Forero-Torres, Andres
通讯作者：
Forero-Torres, Andres
影响因子：
12.8
作者：
Johnston, Patrick B.;Inwards, David J.;Colgan, Joseph P.;Laplant, Betsy R.;Kabat, Brian F.;Habermann, Thomas M.;Micallef, Ivana N.;Porrata, Luis F.;Ansell, Stephen M.;Reeder, Craig B.;Roy, Vivek;Witzig, Thomas E.
通讯作者：
Witzig, Thomas E.