Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats.
Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats.
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脑室内注射 6-羟基多巴胺对大鼠体内稳态的影响。
DOI：
10.1037/h0037638
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
M. Zigmond
中科院分区：
文献类型：
--
作者：
E. Stricker;M. Zigmond
来自雄性白化病Sprague-Dawley大鼠的一系列实验的数据表明，在用去甲丙咪嗪和帕吉林或单独的帕吉林预处理后，脑室内注射6-羟基多巴胺产生严重的脑多巴胺耗竭。与外侧下丘脑损伤的SS一样，这些SS变得无食欲和肥胖，在再次接受干食物和水之前表现出长时间的厌食，保持相对较低的体重，注射2-脱氧葡萄糖后不再增加食物摄入量，并延迟口渴刺激的饮水。然而，不像恢复的阿姆斯壮，他们没有明显的损害的摄食效率，学习味觉厌恶，或热应激过程中的体温调节。结果表明，脑儿茶酚胺在一些监管过程中发挥重要作用，但下丘脑外侧病变可能并不等同于破坏黑质纹状体通路的多巴胺神经元。（4½ p参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Data from a series of experiments with male albino Sprague-Dawley rats show that intraventricular injections of 6-hydroxydopamine after pretreatment with desmethylimipramine and pargyline, or pargyline alone, produced severe depletions of brain dopamine. Like Ss with lateral hypothalamic damage, these Ss became aphagic and adipsic, showed prolonged periods of anorexia before they again accepted dry chow and water, maintained relatively low body weights, no longer increased food intakes after injection of 2-deoxy-dextroglucose, and delayed drinking to thirst stimuli. However, unlike recovered laterals, they did not have marked impairments of feeding efficiency, learned taste aversions, or thermoregulation during heat stress. Results suggest that brain catecholamines play an important role in some regulatory processes, but that lateral hypothalamic lesions may not be tantamount to destruction of the dopamine-containing neurons of the nigrostriatal pathway.(4½ p ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)