Magnetic Resonance Imaging—Controlled Laser–Induced Interstitial Thermotherapy
Magnetic Resonance Imaging—Controlled Laser–Induced Interstitial Thermotherapy
复制标题
磁共振成像——受控激光诱导间质热疗
DOI：
10.1097/00004424-199403000-00015
复制
发表时间：
1994
影响因子：
6.7
通讯作者：
M. Deimling
中科院分区：
文献类型：
--
作者：
B. Gewiese;J. Beuthan;F. Fobbe;D. Stiller;G. Müller;J. Böse;K. Wolf;M. Deimling
激光诱导间质热疗(LIT)可能成为一种有吸引力的微创肿瘤治疗方法。磁共振成像(MRI)可以用来辅助这一过程。方法：研究一种用于激光影响区(肝脏、肌肉)在线监测的TL加权快速低角激发(FLASH)序列。序列参数被优化以获得最大的图像对比度。磁共振成像控制的LITT在体外、体内(兔)和8例人类研究(6例患者)中进行。使用特殊的激光照射器来建立均匀的激光分布。结果：在MRI序列中，LITT区被显示为一个由黑色边界勾勒出的明亮区域。此暗边界对应于45±2℃的等温线，具体取决于所使用的序列参数。结论：利用TL加权Turbo-Flash序列，MRI可用于动态器官间质激光热疗的在线监测。
RATIONALE AND OBJECTIVES.Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure. METHODS.A Tl-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laserinfluenced region (liver, muscle) was investigated. Sequence parameters were optimized for maximal image contrast. Magnetic resonance imaging-controlled LITT was performed in vitro, in vivo (rabbits), and in 8 human investigations (6 patients). Special laser applicators were used to establish a uniform laser light distribution. RESULTS.With the MRI sequence used, the LITT region is visualized as a bright area outlined by a dark border. This dark border corresponds to an isotherm of 45 ± 2 °C depending on the sequence parameters used. CONCLUSION.With the Tl-weighted turbo-FLASH sequence, MRI can be used for on-line monitoring of interstitial laserinduced thermotherapy in moving organs.