Colorectal Cancer: From Genetic Landscape to Targeted Therapy.
Colorectal Cancer: From Genetic Landscape to Targeted Therapy.
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DOI：
10.1155/2021/9918116
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发表时间：
2021
影响因子：
--
通讯作者：
Bennani Mechita M
中科院分区：
文献类型：
--
作者：
El Bali M;Bakkach J;Bennani Mechita M
结直肠癌（CRC）是世界范围内第三大常见癌症类型和第二大死亡原因。对CRC分子通路的理解的进步导致了基于每个肿瘤分子特征的新分类，并通过将靶向治疗整合到临床实践中来改善CRC管理。本文就结直肠癌发生的主要分子通路、分子分类作一综述。还将概述目前用于CRC治疗的抗VEGF和抗EGFR治疗以及正在进行临床研究的治疗，以及抗EGFR单克隆抗体（西妥昔单抗和帕尼单抗）的原发性和获得性耐药机制。靶向治疗已经导致转移性CRC的治疗有了很大的改善。然而，由于结直肠肿瘤的分子异质性，CRC治疗结果存在变异性，这强调了需要确定CRC靶向药物的预后和预测生物标志物。
Colorectal cancer (CRC) is the third most common cancer type and the second cause of death worldwide. The advancement in understanding molecular pathways involved in CRC has led to new classifications based on the molecular characteristics of each tumor and also improved CRC management through the integration of targeted therapy into clinical practice. In this review, we will present the main molecular pathways involved in CRC carcinogenesis, the molecular classifications. The anti-VEGF and anti-EGFR therapies currently used in CRC treatment and those under clinical investigation will also be outlined, as well as the mechanisms of primary and acquired resistance to anti-EGFR monoclonal antibodies (cetuximab and panitumumab). Targeted therapy has led to great improvement in the treatment of metastatic CRC. However, there has been variability in CRC treatment outcomes due to molecular heterogeneity in colorectal tumors, which underscores the need for identifying prognostic and predictive biomarkers for CRC-targeted drugs.
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影响因子：
2.6
作者：
Ágoston EI;Micsik T;Ács B;Fekete K;Hahn O;Baranyai Z;Dede K;Bodoky G;Bursics A;Kulka J;Krenács T;Győrffy B;Harsányi L;Szász AM
通讯作者：
Szász AM
影响因子：
5
作者：
Advani SM;Advani P;DeSantis SM;Brown D;VonVille HM;Lam M;Loree JM;Mehrvarz Sarshekeh A;Bressler J;Lopez DS;Daniel CR;Swartz MD;Kopetz S
通讯作者：
Kopetz S
影响因子：
28.2
作者：
Bardelli A;Corso S;Bertotti A;Hobor S;Valtorta E;Siravegna G;Sartore-Bianchi A;Scala E;Cassingena A;Zecchin D;Apicella M;Migliardi G;Galimi F;Lauricella C;Zanon C;Perera T;Veronese S;Corti G;Amatu A;Gambacorta M;Diaz LA Jr;Sausen M;Velculescu VE;Comoglio P;Trusolino L;Di Nicolantonio F;Giordano S;Siena S
通讯作者：
Siena S
影响因子：
8.4
作者：
Bokemeyer, Carsten;Van Cutsem, Eric;Koehne, Claus-Henning
通讯作者：
Koehne, Claus-Henning
DOI：
10.1111/j.1440-1746.2012.07200.x
发表时间：
2012-09-01
影响因子：
4.1
作者：
Al-Sohaily, Sam;Biankin, Andrew;Warusavitarne, Janindra
通讯作者：
Warusavitarne, Janindra