Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones.
Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones.
复制标题
高血糖会抑制人体葡萄糖的产生，与葡萄糖调节激素的变化无关。
DOI：
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发表时间：
1978
影响因子：
5.8
通讯作者：
R. Sherwin
中科院分区：
文献类型：
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作者：
L. Saccá;R. Hendler;R. Sherwin
为了评估在胰岛素水平不升高的情况下高血糖对肝脏葡萄糖输出的影响，将葡萄糖以0.05-0.15 microM kg-1 min-1的速率输注到6名接受胰岛素恒定输注的青少年发病型糖尿病患者中2小时。在输注葡萄糖之前，胰岛素给药导致血糖（76 +/- 8 mg/dl）和葡萄糖输出量（1.9 +/- 0.1 mg kg-1 min-1）水平稳定。尽管胰岛素输注速率不变且血浆胰高血糖素或儿茶酚胺没有减少，但添加葡萄糖使血糖升高2-3倍，并使葡萄糖输出迅速下降至0.2-0.4 mg kg-1 min-1。当将外源性胰高血糖素（1 ng kg-1-min-1）添加到葡萄糖输注中时，观察到葡萄糖输出量出现类似的下降。我们的结论是，在基础胰岛素水平的存在下，高血糖症抑制葡萄糖输出独立于胰岛素的上升或抗胰岛素激素的下降。
To evaluate the influence of hyperglycemia on hepatic glucose output in the absence of a rise in insulin, glucose was infused for 2 hours into six juvenile-onset diabetics receiving a constant infusion of insulin at a rate of 0.05-0.15 microM kg-1min-1. Prior to the infusion of glucose, insulin administration resulted in stable levels of plasma glucose (76 +/- 8 mg/dl) and glucose output (1.9 +/- 0.1 mg kg-1min-1). The addition of glucose produced a 2-3 fold rise in plasma glucose and a prompt fall in glucose output to 0.2-0.4 mg kg-1min-1, despite the unchanged rate of insulin infusion and the absence of a reduction in plasma glucagon or catecholamines. A similar decline in glucose output was observed when exogenous glucagon (1 ng kg-1-min-1) was added to the glucose infusion. We conclude that in the presence of basal insulin levels hyperglycemia inhibits glucose output independent of a rise in insulin or a fall in anti-insulin hormones.