Oral administration of edible wakame seaweed Undaria pinnatifida (wakame) modifies glucose and lipid metabolism in rats: a DNA microarray analysis.
Oral administration of edible wakame seaweed Undaria pinnatifida (wakame) modifies glucose and lipid metabolism in rats: a DNA microarray analysis.
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口服食用裙带菜海藻裙带菜（裙带菜）可改变大鼠的葡萄糖和脂质代谢：DNA 微阵列分析。
DOI：
10.1002/mnfr.201700828
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
K.
中科院分区：
文献类型：
--
作者：
Yoshinaga;K.;Nakai;Y.;Izumi;H.;Nagaosa;K.;Ishijima;T.;Nakano;T.;Abe;K.
裙带菜是一种可食用的海藻，是日本饮食中的常见成分。先前的研究表明，食用裙带菜与预防代谢综合征有关，但其保护作用的分子机制尚不清楚。方法和结果为观察褐海带裙带菜（裙带菜）摄食对肝脏基因表达的影响，采用每100 g干裙带菜粉含0、0.1和1.0 g的饲料喂养大鼠28天。1%的裙带菜显著降低血清总胆固醇水平。利用DNA芯片分析研究肝脏基因表达，结果表明裙带菜通过下调SREBF‐1抑制脂肪生成途径。此外，上调PPAR信号通路可促进胆汁酸的生物合成和糖异生，从而减少胆固醇的积累和促进β -氧化。结论摄入裙带菜可通过改变SREBF - 1和PPAR信号相关基因的表达影响糖脂代谢。
ScopeWakame is an edible seaweed that is a common constituent in the Japanese diet. Previous studies showed that wakame consumption is associated with the prevention of metabolic syndrome, but the molecular mechanisms underlying the protective effects are poorly understood.Methods and resultsTo determine if the expression of hepatic genes is affected by ingestion of the brown seaweedUndaria pinnatifida(wakame), rats were fed a diet containing 0, 0.1, or 1.0 g per 100 g dried wakame powder for 28 days. Administration of 1% wakame significantly decreased serum total cholesterol levels. Hepatic gene expression was investigated using DNA microarray analysis, and the results showed that wakame suppresses the lipogenic pathway by downregulating SREBF‐1. Moreover, bile acid biosynthesis and gluconeogenesis were promoted by upregulation of the PPAR signaling pathway, which leads to a reduction in the accumulation of cholesterol and promotion of β‐oxidation.ConclusionsThese results suggest that wakame ingestion affects glucose and lipid metabolism by altering the expression of SREBF‐1 and PPAR signal‐related genes.