Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients
Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients
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DOI：
10.1007/s00520-015-3035-8
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发表时间：
2016-06-01
影响因子：
3.1
通讯作者：
Patel, Mrudula
中科院分区：
文献类型：
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作者：
Ramla, Shilpa;Sharma, Vinay;Patel, Mrudula
目的癌症治疗引起的粘膜炎和口腔念珠菌病的表现。本研究旨在探讨从接受治疗的癌症患者中分离的白色念珠菌的毒力特性和抗真菌药敏性。从49名接受癌症治疗的患者和21名健康个体中分离出白色念珠菌，并测量其毒力属性。结果虽然所有研究组的念珠菌携带情况相似，但高数量的念珠菌感染和高浓度的念珠菌感染，以及高浓度的念珠菌感染和高浓度的念珠菌感染，都与真菌的致病力有关。恶性肿瘤患者检出白色念珠菌和多种念珠菌。所有菌株均能产生芽管。与健康个体相比，从放疗和化疗中分离出的酵母菌数量显著增加，产生大量磷脂酶（p < 0.01）。化疗时间的长短与C.白色念珠菌蛋白酶的产生见于来自放射治疗组的显著数量的分离株（p < 0.01）。癌症治疗的类型没有影响。结论产磷脂酶能力较强的梭菌对抗真菌药物的耐药性较低。在接受治疗的癌症患者中，白色念珠菌的数量也随着化疗时间的延长而增加，这表明口腔和全身感染的风险增加。因此，在治疗期间，可以考虑预防性局部抗真菌治疗。
Purpose Cancer treatment causes mucositis and the manifestation of oral candidiasis. This study investigated the virulence properties and antifungal susceptibilities of Candida albicans isolated from cancer patients undergoing therapy.Methods C. albicans were isolated from 49 patients on cancer treatment and 21 healthy individuals and their virulence attributes measured. A correlation was determined between the length of treatment and the fungal counts and their virulence factors.Results Although Candida carriage was similar in all the study groups, high quantities of C. albicans and variety of Candida were found in cancer patients. Germ tubes were produced by all the strains. Significantly high number of yeast isolated from radiotherapy and chemotherapy produced large quantities of phospholipase compared to healthy individuals (p < 0.01). The length of chemotherapy was associated with an increase in the phospholipase production (p = 0.03) by the C. albicans. Proteinase production was seen in a significant number of isolates from the radiotherapy group (p < 0.01). Type of cancer treatment had no effect. Resistance to antifungal agents was low.Conclusions High quantities of phospholipase were produced by C. albicans in cancer patients on therapy which also increased with the length of chemotherapy suggesting enhanced risk of oral and systemic infection. Therefore, during treatment, prophylactic topical antifungal therapy may be considered.