Significance of glycosylation in Notch signaling.
Significance of glycosylation in Notch signaling.
复制标题
DOI：
10.1016/j.bbrc.2014.05.115
复制
发表时间：
2014-10-17
影响因子：
3.1
通讯作者：
Haltiwanger, Robert S.
中科院分区：
文献类型：
--
作者：
Takeuchi, Hideyuki;Haltiwanger, Robert S.
Notch信号传导对于后生动物中的细胞命运特化是必不可少的，并且该途径的失调导致多种人类疾病，包括心脏和血管缺陷以及癌症。Notch细胞外结构域的糖基化已成为调节Notch活性的一种优雅手段，特别是自从2000年发现Fringe是一种修饰O-岩藻糖的糖基转移酶以来。从那时起，细胞外结构域上的几种其他O-聚糖已被证明可调节Notch活性。在这里，我们将描述的分子机制，条纹调制Notch活性的最新结果，总结了最近的工作如何O-葡萄糖，O-GlcNAc，和O-GalNAc聚糖影响Notch，并讨论了几个人类遗传疾病造成的缺陷Notch糖基化。
Notch signaling is essential for cell-fate specification in metazoans, and dysregulation of the pathway leads to a variety of human diseases including heart and vascular defects as well as cancer. Glycosylation of the Notch extracellular domain has emerged as an elegant means for regulating Notch activity, especially since the discovery that Fringe is a glycosyltransferase that modifies O-fucose in 2000. Since then, several other O-glycans on the extracellular domain have been demonstrated to modulate Notch activity. Here we will describe recent results on the molecular mechanisms by which Fringe modulates Notch activity, summarize recent work on how O-glucose, O-GlcNAc, and O-GalNAc glycans affect Notch, and discuss several human genetic disorders resulting from defects in Notch glycosylation.
登录
查看更多内容
DOI：
10.1073/pnas.1200425109
发表时间：
2012-05-08
影响因子：
11.1
作者：
Alfaro, Joshua F.;Gong, Cheng-Xin;Smith, Richard D.
通讯作者：
Smith, Richard D.
影响因子：
4.8
作者：
Andrawes, Marie Blanke;Xu, Xiang;Blacklow, Stephen C.
通讯作者：
Blacklow, Stephen C.
影响因子：
4.8
作者：
Cordle, Jemima;Redfield, Christina;Handford, Penny A.
通讯作者：
Handford, Penny A.
影响因子：
3.2
作者：
Chang, YC;Kwon-Chung, KJ
通讯作者：
Kwon-Chung, KJ
影响因子：
16.8
作者：
Gordon, Wendy R.;Vardar-Ulu, Didem;Blacklow, Stephen C.
通讯作者：
Blacklow, Stephen C.