TGF-beta signaling and the role of inhibitory Smads in non-small cell lung cancer.
TGF-beta signaling and the role of inhibitory Smads in non-small cell lung cancer.
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DOI：
10.1097/jto.0b013e3181ce3afd
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Jen J
中科院分区：
文献类型：
--
作者：
Jeon HS;Jen J
转化生长因子-β (TGF-β) 介导的信号通路参与多种生物学过程，包括细胞生长、分化、血管生成、细胞凋亡和细胞外基质重塑。在癌症中，TGF-β信号传导可以抑制早期肿瘤的生长。然而，在晚期肿瘤中，相同的途径促进肿瘤侵袭和转移。这种矛盾的效应是通过类似于母亲对抗十肢瘫痪或 Smad 蛋白依赖和独立机制介导的，并为靶向癌症治疗提供了机会。本综述总结了 TGF-β 信号转导的分子过程以及导致肺癌进展的抑制性 Smad 的变化。我们还提出了目前针对癌症中 TGF-β 信号通路的合理治疗方法。
The signaling pathway mediated by transforming growth factor-β (TGF-β) participates in various biologic processes, including cell growth, differentiation, angiogenesis, apoptosis, and extracellular matrix remodeling. In the context of cancer, TGF-β signaling can inhibit tumor growth in early-stage tumors. However, in late-stage tumors, the very same pathway promotes tumor invasiveness and metastasis. This paradoxical effect is mediated through similar to mothers against decapentaplegic or Smad protein dependent and independent mechanisms and provides an opportunity for targeted cancer therapy. This review summarizes the molecular process of TGF-β signaling and the changes in inhibitory Smads that contribute to lung cancer progression. We also present current approaches for rational therapies that target the TGF-β signaling pathway in cancer.