What do changes in concentrations of serum surfactant proteins A and D in OSA mean?
What do changes in concentrations of serum surfactant proteins A and D in OSA mean?
复制标题
OSA 中血清表面活性蛋白 A 和 D 浓度的变化意味着什么？
DOI：
10.1007/s11325-014-1106-6
复制
发表时间：
2015-09-01
影响因子：
2.5
通讯作者：
Zhang, Yongping
中科院分区：
文献类型：
--
作者：
Liang, Shao;Li, Nanfang;Zhang, Yongping
目的研究表明，血清表面活性蛋白受氧浓度和机械牵张的影响，但阻塞性睡眠呼吸暂停（OSA）患者血清表面活性蛋白的变化尚不清楚。因此，本研究的目的是检查是否血清中的表面活性蛋白A和D的浓度改变，并与呼吸不足指数（HI）在OSA.MethodsThis是一个横断面研究。本文对140例可疑OSA的男性患者进行了研究。通过PSG和多导睡眠图检查确定OSA。HI ≥ 10.1/h为高HI组，HI < 10.1/h为低HI组。采用标准方法检测Hs-CRP、HbA 1C、FBG，ELISA法检测KL-6、SP-A、SP-D。轻度、中度和重度OSA分别占26.4%、27.8%和24.3%。平均年龄为44.6 ± 7.65岁。与HI较低的受试者相比，HI较高的受试者SP-A（139.54 ± 32.94 vs 158.2 ± 38.9 ng/L，p= 0.005）和SP-D（16.54 ± 3.67 vs 18.10 ± 3.48 ng/L，p= 0.014）较低。夜间HI与血清SP-A水平密切相关（r= 0.343，p = 0.012）和SP-D（r= 0.504，p < 0.001），并与循环SP-A和SP-D水平呈负相关，即使在非吸烟受试者中调整了年龄和体重指数后也是如此。这可能反映了OSA中缺氧的严重程度。
PurposePrevious studies have shown that surfactant proteins are affected by oxygen concentration and mechanic stretches, although the alteration of serum surfactant proteins in individuals with obstructive sleep apnea (OSA) is still unclear. Therefore, the aim of this study is to examine whether serum concentrations of surfactant proteins A and D are altered and related to hypopnea index (HI) in OSA.MethodsThis is a cross-sectional study. Consecutive 140 males, suspicious of OSA, were studied. OSA was determined by PSG and polysomnographic data examined. Subjects with HI ≥ 10.1/h were classified as higher HI group and those with HI < 10.1/h as lower HI group. Hs-CRP, HbA1C, and FBG were determined by standard methods and Krebs von den Lungen-6 (KL-6), surfactant protein-A (SP-A), and surfactant protein-D (SP-D) by ELISA.ResultsOSA was diagnosed in 110 patients (78.5 %). Mild, moderate, and severe OSA constitutes 26.4, 27.8, and 24.3 %, respectively. Mean age was 44.6 ± 7.65 years. Subjects with higher HI had lower SP-A (139.54. ± 32.94 vs 158.2 ± 38.9 ng/L,p= 0.005) and SP-D (16.54 ± 3.67 vs 18.10 ± 3.48 ng/L,p= 0.014) compared to those with lower HI. Nocturnal HI was strongly correlated with serum levels of SP-A (r= 0.343,p= 0.012) and SP-D (r= 0.504,p< 0.001) and are inversely associated with circulating SP-A and SP-D levels, even after adjusting for age and body mass index in nonsmoking subjects.ConclusionsCirculating SP-A and SP-D levels are decreased in some individuals with higher HI in OSA, possibly reflecting severity of hypoxia in OSA.