Pulmonary involvement in adult-onset Still's disease.
Pulmonary involvement in adult-onset Still's disease.
复制标题
DOI：
10.1097/00063198-199909000-00007
复制
发表时间：
1999-09-01
影响因子：
3.3
通讯作者：
Quismorio, F P Jr
中科院分区：
文献类型：
--
作者：
Cheema, G S;Quismorio, F P Jr
成人斯蒂尔病（AOSD）是一种罕见的脾脏疾病，原因不明。AOSD累及其他器官并不罕见，如肝脏、肾脏、骨髓，肺也不常见。本文就AOSD的肺部并发症作一综述。AOSD的肺部受累通常包括胸腔积液或一过性肺浸润，但如果进展为成人呼吸窘迫综合征，则可能危及生命。AOSD患者中也报告了慢性疾病，如限制性肺病。目前唯一可用的治疗方法是大剂量类固醇，尽管其他药物，如静脉注射免疫球蛋白，环磷酰胺和硫唑嘌呤，已经尝试了一些成功。
Adult-onset Still's disease (AOSD) is a rare splenic disorder with an unknown cause. It is not uncommon for AOSD to involve other organs, such as the liver; the kidney; the bone marrow; and, less often, the lungs. In this review, we discuss the pulmonary complications of AOSD. Pulmonary involvement in AOSD usually consists of pleural effusion or transient pulmonary infiltrates, but it may become life threatening if it progresses to the adult respiratory distress syndrome. Chronic conditions, such as restrictive lung disease, have also been reported in patients with AOSD. The only treatment currently available is high-dose steroids, although other agents, such as intravenous immunoglobulin, cyclophosphamide, and azathioprine, have been tried with some success.