Relationship between p53 gene codon-72 polymorphisms and hypertrophic scar formation following caesarean section.
Relationship between p53 gene codon-72 polymorphisms and hypertrophic scar formation following caesarean section.
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p53基因密码子72多态性与剖宫产术后增生性疤痕形成的关系
DOI：
10.3892/etm.2014.1605
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发表时间：
2014-05
影响因子：
2.7
通讯作者：
Lu F
中科院分区：
文献类型：
--
作者：
Gao J;Chen Y;Liao N;Zhao W;Zeng W;Li Y;Wang S;Lu F
The aim of the present study was to determine the relationship between p53 gene codon-72 polymorphisms and hypertrophic scar formation following caesarean section (CS). Blood samples from 260 female patients were collected one week following a CS for the detection of p53 gene polymorphisms using a molecular beacon-coupled quantitative polymerase chain reaction technique. Patients had follow-ups for 12–18 months to observe the scar formation. From these observations, the relationship between the p53 codon-72 polymorphisms and hypertrophic scar formation occurrence was investigated. Among the patients with the CCC/CCC genotype, nine patients had hypertrophic scars and 46 patients showed normal healing, which is a ratio of 0.19. However, the follow-up investigations indicated that the presence of a homozygous or heterozygous C-to-G alteration at the codon-72 site in gene p53 resulted in 13 patients with hypertrophic scars and 192 patients with normal healing, which is a ratio of 0.07. Therefore, these results indicate that patients with the CCC/CCC genotype had a higher risk of developing hypertrophic scars compared with that for patients with the CCC/CGC or CGC/CGC genotypes.
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影响因子：
4.1
作者：
van den Broek, Lenie J.;Kroeze, Kim L.;Gibbs, Susan
通讯作者：
Gibbs, Susan
影响因子：
4
作者：
Kay, C.;Jeyendran, R. S.;Coulam, C. B.
通讯作者：
Coulam, C. B.
影响因子：
4.8
作者：
Aarabi, Shahram;Bhatt, Kirit A.;Gurtner, Geoffrey C.
通讯作者：
Gurtner, Geoffrey C.
影响因子：
9.8
作者：
Albrecht-Schgoer, Karin;Schgoer, Wilfried;Kirchmair, Rudolf
通讯作者：
Kirchmair, Rudolf
影响因子：
4.3
作者：
De Felice, Bruna;Garbi, Corrado;Wilson, Robert R.
通讯作者：
Wilson, Robert R.