HUMAN CELL-MEDIATED CYTOTOXICITY AGAINST MODIFIED TARGET-CELLS IS RESTRICTED BY HLA
HUMAN CELL-MEDIATED CYTOTOXICITY AGAINST MODIFIED TARGET-CELLS IS RESTRICTED BY HLA
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DOI：
10.1038/270526a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
SVEJGAARD, A
中科院分区：
文献类型：
--
作者：
DICKMEISS, E;SOEBERG, B;SVEJGAARD, A
在小鼠中，T细胞介导的病毒感染靶细胞的裂解受到主要组织相容性复合体（MHC）的H-2D和H-2K抗原的限制，在这个意义上，细胞毒性T细胞仅对与杀伤细胞已经被培养的动物共享H-2D和/或H-2K抗原的病毒感染靶细胞有活性1。这些发现使我们更好地理解了MHC调节免疫系统某些功能的方式2，并且在小鼠和豚鼠近交系中的进一步研究中得到了充分的证实，这些研究表明，MHC抗原的限制是这些物种中T细胞介导的免疫应答中的普遍现象3。然而，在人类中，MHC限制免疫反应的证据缺乏，直到有证据表明，一名女性患者排斥来自其HLA相同的兄弟的骨髓移植物，她的血液中有细胞毒性细胞，并且这些细胞的活性仅限于具有与她自己相同的HLA-A2抗原的男性靶细胞4。我们在这里以更普遍的方式表明，人类针对“改变的自身”的细胞介导的细胞毒性受到HLA-A、B和C抗原的限制。
T-CELL-mediated lysis of virus-infected target cells in mice is restricted by the H–2D and H–2K antigens of the major histocompatibility complex (MHC) in the sense that the cytotoxic T cells are only active against virus-infected target cells sharing H–2D and/or H–2K antigens with the animal in which the killer cells have been raised1. These findings led to a better understanding of the way in which the MHC regulates certain functions of the immune system2, and they have been amply confirmed by further studies in inbred strains of mice and guinea pig which have indicated that restriction by antigens of the MHC is a general phenomenon in the T-cell-mediated immune response3in these species. Evidence for MHC restriction of the immune response in man, however, was lacking until it was shown that a female patient who had rejected a bone marrow graft from her HLA-identical brother, had cytotoxic cells in her blood, and that the activity of these cells was restricted to male target cells which had the HLA-A2 antigen in common with herself4. We show here in a more general way, that the cell-mediated cytotoxicity which can be raised in humans against ‘altered self’ is restricted by the HLA-A, B and C antigens.