Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer
Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer
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DOI：
10.1038/modpathol.3800760
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发表时间：
2007-04-01
期刊：
影响因子：
7.5
通讯作者：
Palacios, Jose
中科院分区：
文献类型：
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作者：
Rodriguez-Pinilla, Socorro M.;Sarrio, David;Palacios, Jose
BRCA 1突变携带者和散发性基底细胞样乳腺癌发生的肿瘤具有相似的表型、免疫组化和临床特征。SOX 2是位于染色体3q的胚胎转录因子，该区域经常在散发性基底样和BRCA 1生殖系突变肿瘤中获得。这项研究的目的是确定sox 2的表达是否与基底细胞样散发性乳腺肿瘤有关。采用组织芯片对226例散发性淋巴结阴性浸润性乳腺癌进行雌激素受体（ER）、孕激素受体（PR）、CK 5/6、EGFR、波形蛋白、HER 2、Ki 67、p53和sox 2的免疫组化分析。如果肿瘤为ER/HER 2阴性和CK 5/6和/或EGFR阳性，则认为其具有基底样表型。30例（13.7%）表现为基底细胞样表型。在16.7%的病例中观察到Sox 2表达，并且在基底样乳腺癌中显著更频繁地表达（基底样乳腺癌中43.3%，管腔型乳腺癌中10.6%和HER 2+肿瘤中13.3%，P < 0.001）。此外，Sox 2与ER和PR呈显著负相关（分别为P = 0.001和0.017），与CK 5/6、EGFR和波形蛋白呈显著正相关（分别为P = 0.022、0.005和< 0.001）。Sox 2优先在具有基底细胞样表型的肿瘤中表达，并且可能在定义其分化程度较低的/“干细胞”表型特征中发挥作用。
Tumours arising in BRCA1 mutation carriers and sporadic basal-like breast carcinomas have similar phenotypic, immunohistochemical and clinical characteristics. SOX2 is an embryonic transcription factor located at chromosome 3q, a region frequently gained in sporadic basal-like and BRCA1 germline mutated tumours. The aim of the study was to establish whether sox2 expression was related to basal-like sporadic breast tumours. Two hundred and twenty-six sporadic node-negative invasive breast carcinomas were immunohistochemically analysed for oestrogen receptor (ER), progesterone receptor (PR), CK5/6, EGFR, vimentin, HER2, ki67, p53 and sox2 using tissue microarrays. Tumours were considered to have basal-like phenotype if they were ER/HER2-negative and CK5/6 and/or EGFR-positive. Thirty cases of this series (13.7%) displayed a basal-like phenotype. Sox2 expression was observed in 16.7% of cases and was significantly more frequently expressed in basal- like breast carcinomas (43.3% in basal-like, 10.6% in luminal and 13.3% in HER2+ tumours, P < 0.001). Moreover, Sox2 showed a statistically significant inverse association with ER and PR (P = 0.001 and 0.017, respectively) and direct association with CK5/6, EGFR and vimentin (P = 0.022, 0.005 and < 0.001, respectively). Sox2 is preferentially expressed in tumours with basal-like phenotype and may play a role in defining their less differentiated/'stem cell' phenotypic characteristics.