The Notch pathway in the developing hematopoietic system
The Notch pathway in the developing hematopoietic system
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DOI：
10.1387/ijdb.093049ab
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发表时间：
2010-01-01
影响因子：
0.7
通讯作者：
Espinosa, Lluis
中科院分区：
文献类型：
--
作者：
Bigas, Anna;Robert-Moreno, Alex;Espinosa, Lluis
Notch信号通路的主要功能是在胚胎发育和成体组织稳态过程中产生细胞多样性。这条通路的广泛使用，以及它在进化过程中的保存，表明了它的重要性。在胚胎发育过程中，血管系统和造血系统密切相关，Notch信号负责这两个系统的正确规范。更明确地说，Notch是诱导动脉程序所必需的；然而，它也同时或连续参与造血干细胞的生成。虽然这两种基因程序不同，但它们都在妊娠中期胚胎的背主动脉内皮细胞中实现。动脉和血液发育过程中的这种密切联系阻碍了我们对Notch在造血干细胞生成中的功能的理解。在这里，我们将回顾近年来的工作，显示Notch如何参与小鼠造血的胚胎发育，以及其他生物，如鸡，斑马鱼和苍蝇。
The main function of the Notch signaling pathway is to generate cell diversity during both embryonic development and adult tissue homeostasis. The extended use of this pathway, together with its conservation during evolution, is indicative of its importance. During embryonic development, the vascular and hematopoietic systems are intimately associated and Notch signals are responsible for the correct specification of both systems. More explicitly, Notch is required for the induction of the arterial program; however, it is simultaneously or consecutively also involved in the generation of hematopoietic stem cells. Although both genetic programs are different, they are both implemented in endothelial cells of the dorsal aorta in the midgestation embryo. This close association during the development of arteries and blood has hindered our understanding of Notch function in the generation of hematopoietic stem cells. Here, we will review the work from recent years showing how Notch participates in the embryonic development of hematopoiesis in the mouse, but also in other organisms such as chick, zebrafish and flies.