Nanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy.
Nanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy.
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DOI：
10.1021/jacs.8b01072
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发表时间：
2018-05-02
影响因子：
15
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Lan G;Ni K;Xu Z;Veroneau SS;Song Y;Lin W
免疫疗法已成为一种有前途的癌症疗法，但仅适用于一部分癌症患者。免疫原性光动力疗法（PDT）可以启动肿瘤免疫治疗以提高肿瘤的应答率，但其疗效受到肿瘤缺氧的严重限制。在这里，我们报告了一种纳米级的金属有机框架，铁TBP，作为一种新的nanophotosensitizer克服肿瘤缺氧和敏化有效的PDT，引发非炎症肿瘤的癌症免疫治疗。Fe-TBP由铁氧簇和卟啉配体构建，并在常氧和低氧条件下敏化PDT。Fe-TBP介导的PDT显著提高了抗程序性死亡配体1（α-PD-L1）治疗的疗效，并在结肠直肠癌小鼠模型中引起了远位效应，导致>90%的肿瘤消退。机制研究表明，Fe-TBP介导的PDT诱导显著的细胞毒性T细胞的肿瘤浸润。
Immunotherapy has become a promising cancer therapy, but only works for a subset of cancer patients. Immunogenic photodynamic therapy (PDT) can prime cancer immunotherapy to increase the response rates, but its efficacy is severely limited by tumor hypoxia. Here we report a nanoscale metal–organic framework, Fe-TBP, as a novel nanophotosensitizer to overcome tumor hypoxia and sensitize effective PDT, priming non-inflamed tumors for cancer immunotherapy. Fe-TBP was built from iron-oxo clusters and porphyrin ligands and sensitized PDT under both normoxic and hypoxic conditions. Fe-TBP mediated PDT significantly improved the efficacy of anti-programmed death-ligand 1 (α-PD-L1) treatment and elicited abscopal effects in a mouse model of colorectal cancer, resulting in >90% regression of tumors. Mechanistic studies revealed that Fe-TBP mediated PDT induced significant tumor infiltration of cytotoxic T cells.
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DOI：
10.1038/nrc3239
发表时间：
2012-03-22
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Pardoll DM
通讯作者：
Pardoll DM
影响因子：
38.3
作者：
Luo M;Wang H;Wang Z;Cai H;Lu Z;Li Y;Du M;Huang G;Wang C;Chen X;Porembka MR;Lea J;Frankel AE;Fu YX;Chen ZJ;Gao J
通讯作者：
Gao J
影响因子：
15
作者：
Lu K;He C;Guo N;Chan C;Ni K;Weichselbaum RR;Lin W
通讯作者：
Lin W
影响因子：
38.3
作者：
Spring BQ;Bryan Sears R;Zheng LZ;Mai Z;Watanabe R;Sherwood ME;Schoenfeld DA;Pogue BW;Pereira SP;Villa E;Hasan T
通讯作者：
Hasan T
影响因子：
15
作者：
Wang, Kecheng;Feng, Dawei;Zhou, Hong-Cai
通讯作者：
Zhou, Hong-Cai