Cancer Stem Cells Switch on Tumor Neovascularization
Cancer Stem Cells Switch on Tumor Neovascularization
复制标题
癌症干细胞开启肿瘤新生血管形成
DOI：
10.2174/156652411794474383
复制
发表时间：
2011-02-01
影响因子：
2.5
通讯作者：
Bian, X.-W.
中科院分区：
文献类型：
--
作者：
Ping, Y.-F.;Bian, X.-W.
肿瘤干细胞（cancer stem cells，CSCs）是肿瘤细胞的一个特殊亚群，近年来对CSCs的研究促进了我们对肿瘤发生、新生血管形成、侵袭、耐药和肿瘤复发的认识，为肿瘤的诊断和治疗建立了新的概念。因此，肿瘤干细胞的生物学特性和行为已成为肿瘤研究的前沿。CSC启动肿瘤新生血管形成并促进侵袭，其机制尚未确定。本文综述了肿瘤干细胞在肿瘤血管形成中的作用，并探讨了肿瘤干细胞与血管微环境相互作用的可能机制和治疗意义。
Recent studies on cancer stem cells (CSCs), a special subpopulation of tumor cells, promote our understanding of tumorigenesis, neovascularization, invasion, drug resistance and tumor recurrence, which establishes new concepts for cancer diagnosis and treatment. Therefore, the biological features and behaviors of CSCs have become an exciting frontier of cancer research. CSCs initiate tumor neovascularization and promote invasion with yet to be defined mechanisms. In this review, we provide evidence for the role of CSCs in tumor vascularization and discuss the potential mechanisms and therapeutic significance based on the interaction between CSCs and their vascular niches.