A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans
A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans
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DOI：
10.1034/j.1600-051x.2000.027012889.x
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发表时间：
2000-12-01
影响因子：
6.7
通讯作者：
Kenney, EB
中科院分区：
文献类型：
--
作者：
Camargo, PM;Lekovic, V;Kenney, EB
目的：本研究的目的是评估的临床有效性的牛多孔骨矿物质结合使用的猪衍生的胶原蛋白膜作为屏障，促进牙周再生骨内defects in human.Material和方法：本研究采用了分裂口设计。对22对骨内缺损进行了治疗，并在治疗后6个月通过手术重新植入。实验部位移植牛多孔骨矿物质，并接受胶原蛋白膜引导组织再生。对照组采用开放式皮瓣清创术治疗。结果：术前袋深度，附件水平和跨手术骨测量控制和实验网站是相似的。术后测量结果显示，实验部位的囊袋深度显著减少（颊侧差异为1.89+/-0.31 mm，舌侧差异为0.88+/-0.27 mm），临床附着力增加（颊侧差异为1.51+/-0.33 mm，舌侧差异为1.50+/-0.35 mm）。手术治疗后缺损的再进入显示了明显更大量的缺损填充，有利于实验部位（颊侧测量值的差异为2.67+/-0.91 mm，舌侧测量值的差异为2.54+/-0.87 mm）。本研究的结果表明，使用牛多孔骨矿物质和可吸收，当采用基于引导组织再生原理的技术时，新再生组织与牙根表面之间的附着性质需要进行组织学评估，以确认新附着的存在。
Aim: The purpose of this study was to evaluate the clinical effectiveness of a bovine porous bone mineral used in combination with a porcine derived collagen membrane as a barrier in promoting periodontal regeneration in intrabony defects in humans.Material and Methods: The study employed a split-mouth design. 22 paired intrabony defects were treated and surgically re-entered 6 months after treatment. Experimental sites were grafted with bovine porous bone mineral and received a collagen membrane for guided tissue regeneration. Control sites were treated with an open flap debridement.Results: Preoperative pocket depths, attachment levels and trans-operative bone measurements were similar for control and experimental sites. Post surgical measurements revealed a significantly greater reduction in pocket depth (differences of 1.89+/-0.31 mm on buccal 0.88+/-0.27 mm on lingual measurements) and more gain in clinical attachment (differences of 1.51+/-0.33 mm on buccal and 1.50+/-0.35 mm on lingual measurements) in experimental sites. Surgical reentry of the treated defects revealed a significantly greater amount of defect fill in favor of experimental sites (differences of 2.67+/-0.91 mm on buccal and 2.54+/-0.87 mm on lingual measurements).Conclusions: The results of this study indicate that clinical resolution of intrabony defects can be achieved using a combination of bovine porous bone mineral and an absorbable, porcine derived collagen membrane when employing a technique based on the principles of guided tissue regeneration. The nature of the attachment between the newly regenerated tissue and the root surfaces needs to be evaluated histologically to confirm the presence of new attachment.