OSTEITIS AFTER NEWBORN VACCINATION WITH 3 DIFFERENT BACILLUS-CALMETTE-GUERIN VACCINES - TWENTY-9 YEARS OF EXPERIENCE
OSTEITIS AFTER NEWBORN VACCINATION WITH 3 DIFFERENT BACILLUS-CALMETTE-GUERIN VACCINES - TWENTY-9 YEARS OF EXPERIENCE
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DOI：
10.1097/00006454-199402000-00007
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发表时间：
1994-02-01
影响因子：
3.6
通讯作者：
KATILA, ML
中科院分区：
文献类型：
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作者：
KROGER, L;BRANDER, E;KATILA, ML
自20世纪50年代以来，芬兰的新生儿一直接种卡介苗（BCG）。直到1970年底，疫苗都是由哥德堡的瑞典BCG实验室从哥德堡的BCG菌株制成的，从1971年起，疫苗是由丹麦哥本哈根的相同菌株制成的。1978年被Glare疫苗取代。对卡介苗接种引起的并发症进行了跟踪，并从全国登记处收集了数据。在这项研究中，我们分析了1960年至1988年期间卡介苗骨炎的发病率。从1960年到1970年，发病率为2.7 - 13.0/10万接种卡介苗的婴儿（平均7.3;中位数6.9）。在1971年至1978年期间，发病率增加，在15.3至72.9/10万接种卡介苗的婴儿之间变化（平均值为36.9;中位数为30.4）。自1978年以来，发病率在1.7/10万至10.1/10万卡介苗接种婴儿之间变化（平均值为6.4;中位数为7.2）。在英国，尽管使用了相同的眩光疫苗，但没有发表过BCG骨炎的报告。我们的研究结果表明，在特定人群中卡介苗骨炎的发病率取决于所使用的卡介苗。卡介苗并发症的随访是卡介苗接种计划的重要组成部分。
Newborns in Finland have been vaccinated with Bacillus Calmette-Guerin (BCG) since the 1950s. Until the end of 1970 the vaccine was made from BCG strain Gothenburg by the Swedish BCG laboratory in Gothenburg and from 1971 on from the same strain in Copenhagen, Denmark. It was replaced by the Glare vaccine in 1978. Complications caused by BCG vaccination have been under follow-up, and the data have been collected from nationwide registers. In this study we analyzed the incidence rates of BCG osteitis between the years 1960 and 1988. From 1960 to 1970 the incidence rate was from 2.7 to 13.0/100 000 BCG-vaccinated infants (mean, 7.3; median, 6.9). The incidence increased during the years 1971 to 1978 when it varied between 15.3 and 72.9/100 000 BCG-vaccinated infants (mean, 36.9; median, 30.4). Since 1978 the incidence has varied between 1.7 and 10.1/100 000 BCG-vaccinated infants (mean, 6.4; median, 7.2). In Britain no reports of BCG osteitis have been published despite the use of the same Glare vaccine. Our results indicate that the incidence of BCG osteitis in a given population depends on the BCG vaccine used. The follow-up of BCG complications is an essential part of BCG vaccination program.