Inflammatory cells in acute and chronic asthma.
Inflammatory cells in acute and chronic asthma.
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急性和慢性哮喘中的炎症细胞。
DOI：
10.1164/arrd.1987.135.6p2.s63
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
A. Kay
中科院分区：
文献类型：
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作者：
A. Kay
吸入激发试验和哮喘的进展 有人建议，易感哮喘受试者吸入过敏原以及运动等其他刺激后发生的事件可分为 3 个主要阶段（图 1）。这些被称为（7）快速的，痉挛性的；（2）晚期的，持续的； (3) 亚急性/慢性炎症阶段。这些阶段可能在肥大细胞衍生试剂初始释放后按顺序起作用。常见环境过敏原（例如草花粉提取物或屋尘螨提取物）引起的支气管刺激后气道阻力增加，发病迅速，用力呼气量在一秒内达到峰值（FEVO 发生在 10 至 20 分钟之间（快速、痉挛阶段）。
Inhalational Challenge Tests and the Progression of Asthma It has been suggested that the events which follow allergen inhalation, and perhaps other stimuli such as exercise, in susceptible asthmatic subjects might be divided into 3 main phases (figure 1). These have been termed (7) rapid, spasmogenic;(2) late, sustained; and (3) a subacute/chronic inflammatory phase.The phases might act in sequence after the initial release of mast cell-derived agents. The increase in airways resistance that follows bronchial challenge with common environmental allergens such as extracts of grass pollen or the house dust mite is rapid in onset with a peak fall in the forced expiratory volume in one second (FEVO occurring between 10 and 20 min (rapid, spasmogenic phase).