Hepatitis B Virus Infection and Risk of Nasopharyngeal Carcinoma in Southern China
Hepatitis B Virus Infection and Risk of Nasopharyngeal Carcinoma in Southern China
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中国南方地区乙型肝炎病毒感染与鼻咽癌风险。
DOI：
10.1158/1055-9965.epi-15-0344
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发表时间：
2015-11-01
影响因子：
3.8
通讯作者：
Cao, Su-Mei
中科院分区：
文献类型：
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作者：
Ye, Yan-Fang;Xiang, Yan-Qun;Cao, Su-Mei
背景：乙肝病毒感染是否在鼻咽癌的发生发展中起作用在很大程度上尚不清楚。本研究旨在探讨中国南方地区鼻咽癌发病与乙肝病毒感染的关系。方法：对711例鼻咽癌患者和两组对照进行病例对照研究。第一组由656例与乙肝病毒感染无关的其他良性肿瘤患者组成，第二组由680名健康人群组成。结果：鼻咽癌患者抗-HBc抗体阳性率为47.26%，明显高于良性肿瘤对照组(39.33%；P<0.01)和健康对照组(41.18%；P=0.04)。在调整鼻咽癌危险因素的多因素模型中，抗-HBc-(+)与鼻咽癌的危险性显著相关[调整后OR(AOR)为1.40；95%CI为1.12~1.74，与良性肿瘤对照及AOR为1.48；95%CI为1.05~2.08与健康对照相比]。这种关联不受乙肝表面抗原(HBs Ag)状态的影响。与健康对照组相比，同时携带抗-HBc-(+)和EB病毒抗体的个体患鼻咽癌的风险显著增加(AOR，141.82；95%CI，68.73-292.62)。结论：我们的研究提示，中国南方地区乙肝病毒感染与鼻咽癌的发病风险有关。(C)2015年AACR。
Background: Whether or not hepatitis B virus (HBV) infection plays a role in the development of nasopharyngeal carcinoma (NPC) is largely unknown. Our study aimed to assess the association between HBV infection and the risk of NPC in Southern China.Methods: We conducted a case-control study including 711 NPC cases and two groups of controls. The first control group consisted of 656 individuals with other benign tumors unrelated to HBV infection and the second group consisted of 680 healthy population controls. Multivariable ORs and corresponding 95% confidence intervals (CI) for NPC were estimated by logistic regression.Results: Patients with NPC had higher prevalence of antibodies against hepatitis B core antigen-positive [anti-HBc-(+); 47.26%] compared with either benign tumor controls (39.33%; P < 0.01) or healthy controls (41.18%; P = 0.04). In multivariable models adjusting for a set of risk factors for NPC, anti-HBc-(+) was significantly associated with a higher risk of NPC [adjusted OR (AOR), 1.40; 95% CI, 1.12-1.74 compared with the benign tumor controls and AOR, 1.48; 95% CI, 1.05-2.08 compared with the healthy controls]. The association was not modified by hepatitis B surface antigen (HBsAg) status. Finally, compared with the healthy controls, individuals with both anti-HBc-(+) and EBV antibodies had largely increased risk of NPC (AOR, 141.82; 95% CI, 68.73-292.62).Conclusion: Our study suggests that HBV infection is associated with NPC risk in Southern China.Impact: Prevention for HBV infection may play a role in the development of NPC. (C) 2015 AACR.