EFFECT OF RUSH IMMUNOTHERAPY IN HOUSE-DUST-MITE (HDM)-SENSITIVE ADULT BRONCHIAL-ASTHMA - CHANGES IN IN-VIVO AND IN-VITRO RESPONSES TO HDM
EFFECT OF RUSH IMMUNOTHERAPY IN HOUSE-DUST-MITE (HDM)-SENSITIVE ADULT BRONCHIAL-ASTHMA - CHANGES IN IN-VIVO AND IN-VITRO RESPONSES TO HDM
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DOI：
10.2169/internalmedicine.32.702
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发表时间：
1993-09-01
影响因子：
1.2
通讯作者：
DOHI, Y
中科院分区：
文献类型：
--
作者：
NAGATA, M;YAMAMOTO, H;DOHI, Y
本研究采用开放性研究方法，观察了急冲免疫治疗（RI）后小鼠对屋尘螨（HDM）的体内外反应变化。对12名患有HDM敏感性哮喘的受试者进行了为期7天的RI方案，使用含有HDM过敏原的提取物，并在RI后16或20周内评估了对支气管反应性和血清抗体水平的影响。HDM特异性IgG、IgG 1和IgG 4抗体水平在RI后4或8周显著升高。在RI后16 - 20周，所有受试者吸入过敏原导致FEV 1（PD 20）下降20%的激发剂量均升高。log-PD 20的增加与HDM特异性IgG 4/IgG 1比值的增加高度相关（r=0.68，p
An open study was conducted to evaluate the changes in in vivo and in vitro responses to house-dust-mite (HDM) after rush immunotherapy (RI). A 7-day RI protocol using an extract containing HDM allergen was administered to 12 subjects with HDM-sensitive asthma, and the effects on bronchial responsiveness and serum antibody levels were evaluated up to 16 or 20 weeks after RI. The levels of HDM-specific IgG, IgG1 and IgG4 antibodies were significantly elevated from 4 or 8 weeks after RI. Provocative doses causing a 20% fall in FEV1 (PD20) by allergen inhalation were elevated in all subjects at 16 to 20 weeks after RI. There was a high correlation between the increase in log-PD20 and the increase in the ratio of HDM-specific IgG4 to IgG1 (r=0.68, p