2-TIERED REGULATION OF SPATIALLY PATTERNED ENGRAILED GENE-EXPRESSION DURING DROSOPHILA EMBRYOGENESIS
2-TIERED REGULATION OF SPATIALLY PATTERNED ENGRAILED GENE-EXPRESSION DURING DROSOPHILA EMBRYOGENESIS
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DOI：
10.1038/332604a0
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发表时间：
1988-04-14
期刊：
影响因子：
64.8
通讯作者：
OFARRELL, PH
中科院分区：
文献类型：
--
作者：
DINARDO, S;SHER, E;OFARRELL, PH
一个调控级联反应，在胚胎发生的合胞体阶段开始，最终在细胞胚盘阶段的锯齿状基因表达的条纹图案。早期的调控基因，例如配对规则基因，是瞬时表达的，当它们的产物衰变时，一个涉及片段极性基因的独特调控程序接管。这个晚期程序通过可能涉及细胞通讯的相互作用维持并可能修改了交错表达的条纹模式。
A regulatory cascade, initiated during the syncytial stage of embryogenesis, culminates in the striped pattern of engrailed gene expression at the cellular blastoderm stage. The early regulatory genes, for example the pair-rule genes, are expressed transiently and as their products decay a distinct regulatory programme involving segment polarity genes takes over. This late programme maintains and perhaps modifies the striped pattern of engrailed expression through interactions that may involve cell communication.