Radioimmunodetection of melanoma utilizing In-111 96.5 monoclonal antibody: a preliminary report.
Radioimmunodetection of melanoma utilizing In-111 96.5 monoclonal antibody: a preliminary report.
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利用 In-111 96.5 单克隆抗体对黑色素瘤进行放射免疫检测：初步报告。
DOI：
10.1148/radiology.155.2.3983401
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发表时间：
1985
期刊：
影响因子：
19.7
通讯作者：
J. Frincke
中科院分区：
文献类型：
--
作者：
S. Halpern;R. Dillman;K. Witztum;J. F. Shega;P. Hagan;W. M. Burrows;J. Dillman;M. Clutter;R. Sobol;J. Frincke
用鼠抗黑色素瘤单抗(MOAB)标记In-111，对21例确诊或疑似黑色素瘤转移的患者给予1~20 mg。对一名患者进行了两次研究。在4名患者中，未标记的96.5单抗在接受放射药物治疗之前给予。所有患者都能耐受该手术，且无毒副作用，无论用药摩押的质量如何。扫描由两名观察员解读，一名完全知情，另一名对案件一无所知。增加摩押质量或在注射In-111摩押之前预先输注未标记的摩押，会导致血清半衰期延长，并似乎提高了肿瘤的检出能力。病变最好在注射后72小时或更晚出现。在所有有转移性疾病的患者中，至少有一个肿瘤部位是明显的。当考虑到所有剂量的数据时，知道病例的医生发现了已知的1.5厘米或更大的已知病变的56%。在患者的体检中发现了八个没有怀疑的病变。如果把这些都包括在内，检测率就会上升到61%。49%是由另一位医生发现的。没有使用减法技术。单光子发射计算机断层扫描通常比平面成像技术更好地显示病变。96.5In-111单抗似乎对检测转移性黑色素瘤有实用价值。96.5英寸-111摩押的进一步临床评估是有必要的。
The murine 96.5 monoclonal antimelanoma antibody (MoAb) was labeled with In-111, and 1-20 mg were administered to 21 patients who had proved or suspected melanoma metastases. One patient was studied twice. In four patients, unlabeled 96.5 MoAb was administered prior to the radiopharmaceutical. All of the patients tolerated the procedure without toxicity regardless of the mass of MoAb administered. The scans were interpreted by two observers, one with full knowledge, the other with no knowledge of the cases. Increasing the MoAb mass or preinfusing unlabeled MoAb prior to the administration of In-111 MoAb resulted in a prolongation of the serum half time, and appeared to improve tumor detection. Lesions were best seen at 72 hours after infusion or later. In all patients who had metastatic disease, at least one tumor site was apparent. Fifty-six per cent of known lesions 1.5 cm or greater in size were detected by the physician who had knowledge of the cases when data from all doses were considered. There were eight lesions detected that were not suspected in the workup of the patient. When these are included, the detection rate rises to 61%. Forty-nine per cent were detected by the other physician. Subtraction techniques were not employed. Lesions were often better seen with single photon emission computed tomography than with planar imaging techniques. The 96.5 In-111 MoAb appears to have utility for the detection of metastatic melanoma. Further clinical evaluation of 96.5 In-111 MoAb is warranted.