Sequences of abstract nonbiological stimuli share ventral premotor cortex with action observation and imagery
Sequences of abstract nonbiological stimuli share ventral premotor cortex with action observation and imagery
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DOI：
10.1523/jneurosci.1169-04.2004
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发表时间：
2004-06-16
影响因子：
5.3
通讯作者：
von Cramon, DY
中科院分区：
文献类型：
--
作者：
Schubotz, RI;von Cramon, DY
由观察到的或想象的动作触发的激活表明，腹侧运动前皮质(PMV)提供了一个动作词汇，使我们能够检测和预测观察到的动作中基本不变的感知状态。在本研究中，我们检验了这样的假设，即只要必须处理刺激的时间顺序，相同的PMV区域也被非生物(抽象)刺激序列招募。使用功能磁共振成像，我们指导参与者评估观察到的动作[外部生物线索(EB)]、运动想象[内部生物线索(IB)]或几何图形序列[外部非生物线索(EN)]的预期结果。正如假设的那样，我们发现，与顺序的目标检测控制任务相比，每个条件都在PMV[左半球，布罗德曼区(BA)6]内引发了显著的激活。此外，在仅参与生物(动作)线索(EB，IB)和非生物线索(EN)任务的区域中，线索特异性激活被识别出来。生物线索任务在与PMV相邻的额下回(BA 44/45)、额内侧壁、纹状体外区、颞后上沟、躯体感觉皮质和杏仁-海马区被激活，而非生物线索任务则激活基底节的补充前运动区、额中回、顶内沟和尾状核。总而言之，研究结果指出，运动前状态对顺序结构化事件的表征或加工有基本的贡献，并辅之以生物或非生物线索背景下的不同区域集合。
Activation triggered by either observed or imagined actions suggests that the ventral premotor cortex (PMv) provides an action vocabulary that allows us to detect and anticipate basically invariant perceptual states in observed actions. In the present study, we tested the hypothesis that the same PMv region is also recruited by nonbiological ( abstract) stimulus sequences as long as the temporal order of stimuli has to be processed. Using functional magnetic resonance imaging, we instructed participants to assess expected outcomes in observed actions [ external biological cues (EB)], motor imagery [ internal biological cues (IB)], or geometrical figure sequences [ external nonbiological cues ( EN)]. As hypothesized, we found that each condition elicited significant activation within PMv [ left hemisphere, Brodman Area ( BA) 6], in contrast to a sequential target detection control task. In addition, cue-specific activations were identified in areas that were only engaged for biologically ( action) cued ( EB, IB) and nonbiologically cued ( EN) tasks. Biologically cued tasks elicited activations within inferior frontal gyri adjacent to PMv ( BA 44/45), in the frontomedian wall, the extrastriate body area, posterior superior temporal sulci, somatosensory cortices, and the amygdala-hippocampal-area, whereas the nonbiologically cued task engaged presupplementary motor area, middle frontal gyri, intraparietal sulci, and caudate nuclei of the basal ganglia. In sum, findings point to a basic premotor contribution to the representation or processing of sequentially structured events, supplemented by different sets of areas in the context of either biological or nonbiological cues.