Transcranial direct current stimulation improves recognition memory in Alzheimer disease
Transcranial direct current stimulation improves recognition memory in Alzheimer disease
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DOI：
10.1212/01.wnl.0000317060.43722.a3
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发表时间：
2008-08-12
期刊：
影响因子：
9.9
通讯作者：
Priori, A.
中科院分区：
文献类型：
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作者：
Ferrucci, R.;Mameli, F.;Priori, A.
目的：目的：探讨经颅直流电刺激（tDCS）对阿尔茨海默病（AD）患者颞顶区认知功能的影响。方法：对10例AD患者进行3次经颅直流电刺激（AtDCS）、阴极tDCS（CtDCS）和假tDCS（StDCS）。在每一个会话中，在基线时测试识别记忆和视觉注意力（刺激前）和tDCS结束后30分钟结果：AtDCS后，单词再认记忆任务的准确性增加，（刺激前：15.5 +/- 0.9，刺激后：17.9 +/- 0.8，p = 0.0068），而在CtDCS后，（15.8 ± 0.6 vs 13.2 ± 0.9，p = 0.011），StDCS后保持不变（16.3 ± 0.7 vs 16.0 ± 1.0，p = 0.75）。结论：经颅直流电刺激（tDCS）对阿尔茨海默病（AD）患者的再认记忆有特异性影响。由于tDCS简单、安全且廉价，我们的发现提示了使用重复tDCS与其他治疗干预措施联合治疗AD患者的研究。
Objective: To evaluate the cognitive effect of transcranial direct current stimulation (tDCS) over the temporoparietal areas in patients with Alzheimer disease (AD).Methods: In 10 patients with probable AD, we delivered anodal tDCS (AtDCS), cathodal tDCS (CtDCS), and sham tDCS (StDCS) over the temporoparietal areas in three sessions. In each session recognition memory and visual attention were tested at baseline (prestimulation) and 30 minutes after tDCS ended (poststimulation).Results: After AtDCS, accuracy of the word recognition memory task increased (prestimulation: 15.5 +/- 0.9, poststimulation: 17.9 +/- 0.8, p = 0.0068) whereas after CtDCS it decreased (15.8 +/- 0.6 vs 13.2 +/- 0.9, p = 0.011) and after StDCS it remained unchanged (16.3 +/- 0.7 vs 16.0 +/- 1.0, p = 0.75). tDCS left the visual attention-reaction times unchanged.Conclusion: Transcranial direct current stimulation (tDCS) delivered over the temporoparietal areas can specifically affect a recognition memory performance in patients with Alzheimer disease (AD). Because tDCS is simple, safe and inexpensive, our finding prompts studies using repeated tDCS, in conjunction with other therapeutic interventions for treating patients with AD.