CARDIOVASCULAR EFFECTS OF 5-HT1A RECEPTOR AGONISTS INJECTED INTO THE DORSAL RAPHE NUCLEUS OF CONSCIOUS RATS
CARDIOVASCULAR EFFECTS OF 5-HT1A RECEPTOR AGONISTS INJECTED INTO THE DORSAL RAPHE NUCLEUS OF CONSCIOUS RATS
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DOI：
10.1016/0014-2999(90)90493-p
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发表时间：
1990-06-21
影响因子：
5
通讯作者：
HIGGINS, GA
中科院分区：
文献类型：
--
作者：
CONNOR, HE;HIGGINS, GA
The aim of this study was to investigate the cardiovascular effects of the 5-HT1A receptor agonists, 8-OH-DPAT (8-hydroxy-2(di-n-propylamino)tetralin), flesinoxan and 5-carboxamidotryptamine (5-CT) following infection into the dorsal raphe nucleus of conscious rats. 8-OH-DPAT (0.5-2.5 .mu.g), flesinoxan (2.5-5.0 .mu.g) and 5-CT (0.05 .mu.g g) caused hypotension, bradycardia and flat body posture. In contrast, injection of 8-OH-DPAT (0.5- .mu.g) into the median raphe nucleus caused no cardiovascular changes or flat body posture. (-)Pindolol (0.5 .mu.g dorsal raphe nucleus) had little effect on cardiovascular parameters, but significantly attentuated the cardiovascular effects of 8-OH-DPAT (0.5 .mu.g dorsal raphe nucleus). N-Methylatropine (1 mg/kg i.v.) antagonised the cardivascular effects of 8-OH-DPAT (0.5 .mu.g dorsal raphe nucleus), suggesting these were vagally mediated. Both pretreatments also appeared to reduce 8-OH-DPAT-induced flat body posture. The results suggest that 8-OH-DPAT activates 5-HT1A receptors in the dorsal raphe nucleus to cause hypotension and bradycardia.
