Motor system alterations in retired former athletes: the role of aging and concussion history
Motor system alterations in retired former athletes: the role of aging and concussion history
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DOI：
10.1186/1471-2377-13-109
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发表时间：
2013-08-26
期刊：
影响因子：
2.6
通讯作者：
Theoret, Hugo
中科院分区：
文献类型：
--
作者：
De Beaumont, Louis;Tremblay, Sebastien;Theoret, Hugo
背景资料：有运动性脑震荡史的退役运动员随着年龄的增长会经历认知和运动能力的下降，并且在这一人群中严重神经退行性疾病的风险会被放大。本研究调查了年龄对运动系统代谢和功能的影响，这些运动员在测试前几十年一直遭受脑震荡。方法：为了验证年龄和远程脑震荡诱导运动系统功能和代谢改变的假设，我们使用质子磁共振波谱检测初级运动皮层和系列反应时间任务（SRTT）的代谢异常，结果：我们的研究结果表明，运动学习是显着减少前脑震荡运动员相对于控制。此外，谷氨酸/H2O的比例在M1中不成比例地减少脑震荡的运动员随着年龄的增长，并被发现与运动学习impairments.Conclusion：这项研究的结果提供的证据表明，收购一个重复的运动序列受到损害的老化脑震荡的大脑，其生理基础可能牵连不成比例地减少M1谷氨酸浓度随着年龄的增长。
Background: Retired athletes with a history of sports concussions experience cognitive and motor declines with aging, and the risk of severe neurodegenerative conditions is magnified in this population. The present study investigated the effects of aging on motor system metabolism and function in former university-level athletes who sustained their last concussion several decades prior to testing.Methods: To test the hypothesis that age and remote concussions induce functional as well as metabolic alterations of the motor system, we used proton magnetic resonance spectroscopy to detect metabolic abnormalities in the primary motor cortex and the serial reaction time task (SRTT) to evaluate motor learning.Results: Our results indicate that motor learning is significantly reduced in former concussed athletes relative to controls. In addition, glutamate/H2O ratio in M1 was disproportionately reduced in concussed athletes with advancing age and was found to strongly correlate with motor learning impairments.Conclusion: Findings from this study provide evidence that the acquisition of a repeated motor sequence is compromised in the aging concussed brain and that its physiological underpinnings could implicate disproportionate reductions of M1 glutamate concentrations with advancing age.