Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease
Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease
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DOI：
10.1016/j.cca.2006.05.005
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发表时间：
2006-11-01
影响因子：
5
通讯作者：
Madhusudhan, Basavaraj
中科院分区：
文献类型：
--
作者：
Sarkar, Purnima Dey;Shivaprakash, T. M.;Madhusudhan, Basavaraj
背景：南亚人，尤其是印度人患动脉粥样硬化的风险更高，冠状动脉疾病的死亡率也更高。年轻患者冠心病发病率的上升可能与工业化、生活压力大、运动少、吸烟发生率增加等因素有关。我们试图确定对氧磷酶与年轻患者冠状动脉疾病的独立关联。方法：对120例经血管造影证实合并糖尿病、吸烟、高脂血症、肥胖、高血压的早发冠心病患者（男99例，女21例，均< 45岁）与50例正常人（男41例，女9例）进行血脂及血清对氧磷酶测定比较。结果：早发冠心病患者总胆固醇、甘油三酯和低密度脂蛋白胆固醇浓度明显升高。与对照组相比，冠心病患者的对氧磷酶活性和高密度脂蛋白胆固醇浓度下降。结论：对氧磷酶是冠心病患者的独立危险因素（p < 0.001， OR为14.9,95% CI为5.6-35.9）。在没有传统危险因素的情况下，所有冠状动脉疾病患者都应评估对氧磷酶活性。(c) 2006 Elsevier B.V.版权所有
Background: South Asians, especially Indians show increased risk for atherosclerosis and have the higher mortality rates due to coronary artery disease. The increasing incidence of coronary artery disease in young patients is possibly due to industrialization, stress of life, less exercise and increasing incidence of smoking and other factors. We attempted to determine an independent association of paraoxonase with coronary artery disease in young patients.Method: The lipid profile and serum paraoxonase were investigated,in 120 angiographically-proven premature coronary artery disease patients (99 males and 21 females, all < 45 years) with diabetes mellitus, smoking, hyperlipidemia, obesity, hypertension along with 50 (41 male and 9 female) normal subjects and compared.Results: A significant increase was observed in the concentrations of total cholesterol, triglycerides and LDL cholesterol in premature coronary artery disease patients. The activities of paraoxonase and HDL cholesterol concentrations decreased in coronary artery disease patients compared to control subjects.Conclusion: A paraoxonase was an independent (p < 0.001, OR 14.9 and 95% CI 5.6-35.9) risk factor for premature coronary artery disease patients along with lipid profiles. Paraoxonase activity should be evaluated in all coronary artery disease patients in the absence of traditional risk factors. (c) 2006 Elsevier B.V. All rights reserved.