Reactive oxygen species-responsive and scavenging polyurethane nanoparticles for treatment of osteoarthritis in vivo
Reactive oxygen species-responsive and scavenging polyurethane nanoparticles for treatment of osteoarthritis in vivo
复制标题
活性氧响应和清除聚氨酯纳米粒子用于治疗体内骨关节炎
DOI：
10.1016/j.cej.2020.128147
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发表时间：
2021-04
影响因子：
15.1
通讯作者：
Gao Changyou
中科院分区：
文献类型：
--
作者：
Zhang Haolan;Xiong Hao;Ahmed Wajiha;Yao Yuejun;Wang Shuqin;Fan Cunyi;Gao Changyou
Excessive reactive oxygen species (ROS) were closely associated with the progression of osteoarthritis (OA) in terms of symptoms and aggravation. To combine the advantages of ROS-stimuli responsiveness with scavenging ability, a novel polythioketal urethane (PTKU) was synthesized by simple and direct reaction between polythioketal (PTK) and diisocyanate. Apart from the excellent mechanical properties, the PTKU could be fabricated into various formulations, for example, nanoparticles (NPs) loaded with anti-inflammatory drug, dexamethasone. The PTKU@DEX NPs were capable of scavenging several kinds of ROS, accompanying with the degradation of polymers.In vitroevaluation with macrophages revealed that the PTKU and PTKU@DEX NPs had low cytotoxicity, and could suppress the intracellular ROS and expression of hypoxia inducible factor-1α (HIF-1α). Injection of the PTKU and PTKU@DEX NPs to OAin vivocould significantly reduce the ROS level in articular cavity and alleviate destruction of oxidative stress, and resulted in a lower ratio of inflammatory M1 macrophages and a higher level of anti-inflammatory M2 macrophages. The synergistic effects of ROS-responsive drug delivery and ROS scavenging PTKU promoted significantly the therapeutic outcome of OA with a best score close to the normal cartilage, revealing the great promise of PTKU in treatment of OAin vivo.
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影响因子：
5.2
作者：
Scheschowitsch K;Leite JA;Assreuy J
通讯作者：
Assreuy J
影响因子：
27.4
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Nwosu LN;Mapp PI;Chapman V;Walsh DA
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Walsh DA
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14
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16.6
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4.8
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通讯作者：
Allison, GT