The-1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: A meta-analysis
The-1082A/G polymorphism in the Interleukin-10 gene and the risk of rheumatoid arthritis: A meta-analysis
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DOI：
10.1016/j.cyto.2011.05.022
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发表时间：
2011-11-01
期刊：
影响因子：
3.8
通讯作者：
Lu, Jianxi
中科院分区：
文献类型：
--
作者：
Zhang, Jie;Zhang, Yonggang;Lu, Jianxi
大量研究表明，白细胞介素-10基因(IL-10) -1082A/G多态性（rs1800896）与类风湿关节炎（RA）易感性有关。然而，结果是不一致和不确定的。本研究旨在通过荟萃分析分析IL-10基因-1082A/G多态性与RA风险的关系。本荟萃分析共纳入10项病例对照研究的1480例病例和1413例对照。结果表明，与纯合子M相比，G等位基因携带者（GG + GA）患RA的风险降低25%(优势比（OR) = 0.75, 95%可信区间（CI）： 0.59 ~ 0.93）。在欧洲的分析中，G等位基因携带者的风险显著降低（OR = 0.73, 95% CI: 0.57-0.93, GG + GA vs. AA）。这项荟萃分析的结果为IL-10 -1082A/G多态性与RA风险之间的关联提供了证据。为了进一步评估基因x基因和基因x环境在IL-10基因多态性与RA风险之间的相互作用，需要更多的大组患者研究。(C) 2011 Elsevier Ltd.版权所有。
A large number of studies have shown that the -1082A/G polymorphism (rs1800896) in the Interleukin-10 gene (IL-10) is implicated in the susceptibility to rheumatoid arthritis (RA). However, the results are inconsistent and inconclusive. The aim of this study is to analyze the association between the -1082A/G polymorphism in the IL-10 gene and the RA risk by meta-analysis. A total of 1480 cases and 1413 controls in 10 case-control studies were included in this meta-analysis. The results indicated that the G allele carriers (GG + GA) had a 25% decreased risk of RA, when compared with the homozygote M (odds ratio (OR) = 0.75, 95% confidence interval (CI): 0.59-0.93). In the analysis in Europeans, significant decreased risks were associated with the G allele carriers (OR = 0.73 and 95% CI: 0.57-0.93 for GG + GA vs. AA). The results from this meta-analysis provide evidence for the association between the IL-10 -1082A/G polymorphism and the risk of RA. To further evaluate gene x gene and gene x environment interactions between the polymorphisms in the IL-10 gene and RA risk, more studies with large groups of patients are required. (C) 2011 Elsevier Ltd. All rights reserved.