Prognostic value of masticatory muscle involvement in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy
Prognostic value of masticatory muscle involvement in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy
复制标题
咀嚼肌受累对接受调强放射治疗的鼻咽癌患者的预后价值。
DOI：
10.1016/j.oraloncology.2017.11.002
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发表时间：
2017-12-01
期刊：
影响因子：
4.8
通讯作者：
Wang, Rensheng
中科院分区：
文献类型：
--
作者：
Kang, Min;Zhou, Pingting;Wang, Rensheng
背景和目的：2017年，国际癌症控制联盟/美国癌症联合委员会（UICC/AJCC）发布的第8版鼻咽癌（NPC）分期手册定义了关于解剖咀嚼肌（MM）参与的新规则。方法：回顾性分析2008年1月至2010年3月间608例接受调强放疗（IMRT）的鼻咽癌患者的临床资料。结果：398例（65.4%）鼻咽癌患者合并MM。我们观察到总生存率的显著差异（OS; 75.6% vs. 86.7%，P=.043）和局部无复发生存率（LRFS; 81.5% vs. 88.6%，P= 0.048），但无远处转移生存率无差异（DMFS; 80.3% vs. 85.0%，P=.147）或无病生存率（DFS; 77.9% vs. 81.6%，P=.081）。不同类型的多发性骨髓瘤患者的OS和LRFS也存在显著差异。单因素和多因素分析显示，与同时侵犯翼外肌（LP）的患者相比，仅侵犯翼内肌（MP）的患者的OS和LRFS率更高（P
Background and Purpose: In 2017, the 8th edition of the nasopharyngeal carcinoma (NPC) staging manual published by the Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) defined new rules regarding the involvement of anatomical masticatory muscles (MM). The purpose of this study is to evaluate the validity of the current T-staging system after the addition of revisions regarding MM involvement.Methods: We performed a retrospective review of 608 patients, who were newly diagnosed with NPC and treated with intensity-modulated radiotherapy (IMRT) between January 2008 and March 2010.Results: We found MM involvement in 398 NPC cases (65.4%). We observed a significant difference in overall survival (OS; 75.6% vs. 86.7%, P=.043) and in local relapse-free survival (LRFS; 81.5% vs. 88.6%, P=.048) between patients with and without MM involvement, but no difference in distant metastasis-free survival (DMFS; 80.3% vs. 85.0%, P=.147) or disease-free survival (DFS; 77.9% vs. 81.6%, P=.081). Significant differences in OS and LRFS were also found among different types of MM involvement. Compared with patients who had concurrent involvement of the lateral pterygoid muscle (LP), patients with tumors invading only the medial pterygoid muscle (MP) had a higher OS and LRFS rates, according to univariate and multivariate analysis (P