Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms
Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms
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DOI：
10.1093/hmg/ddr588
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发表时间：
2012-04-01
影响因子：
3.5
通讯作者：
Smith, George Davey
中科院分区：
文献类型：
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作者：
Steer, Colin D.;Hibbeln, Joseph R.;Smith, George Davey
在小型研究中，脂肪酸脱饱和酶(FADS)基因簇中的少量多态等位基因与前体多不饱和脂肪酸(FAs)的脱饱和度降低有关。这些多态在进展性发育阶段的作用以前还没有报道。为探讨FADS2基因rs1535和rs174575两个多态性与多不饱和脂肪酸的关系，对4342名孕妇、3343条反映新生儿血液供应的脐带和5240名7岁儿童的血液样本进行了分析。这两个标记的G等位基因与底物亚油酸(18：2n-6)和亚麻酸(18：3n-3)呈显著正相关，尤其是rs1535。较高的不饱和脂肪酸如花生四烯酸(20：4n-6)、铁氰酸(EPA，20：5n-3)和鹿角酸(DHA，22：6n-3)呈负相关。使用母亲和孩子基因类型的双变量遗传关联表明，与高度不饱和的omega-3脂肪酸相比，新生儿的新陈代谢具有更大的合成高度不饱和omega-6脂肪酸的能力。然而，尽管新生儿还不成熟，有证据表明DHA的合成正在发生。然而，到7岁时，没有观察到与母体基因相关的情况。这表明，儿童的FA水平只与他们自己的代谢有关，没有明显的持续的宫内环境影响。
Minor alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been associated with reduced desaturation of the precursor polyunsaturated fatty acids (FAs) in small studies. The effects of these polymorphisms during progressive developmental stages have not previously been reported. Data from blood samples for 4342 pregnant women, 3343 umbilical cords reflecting the newborns blood supply and 5240 children aged 7 years were analysed to investigate the associations of polyunsaturated FAs with rs1535 and rs174575two polymorphisms in the FADS2 gene. Strong positive associations were observed between the minor G allele for these two markers, especially rs1535, and the substrates linoleic (18:2n-6) and -linolenic (18:3n-3) acid. Negative associations were observed for the more highly unsaturated FAs such as arachidonic acid (20:4n-6), timnodonic acid (EPA, 20:5n-3) and cervonic acid (DHA, 22:6n-3). Bivariable genetic associations using the mother and child genotypes suggested that the newborn metabolism had a greater capacity to synthesize the more highly unsaturated omega-6 FAs than the more highly unsaturated omega-3 FAs. Nevertheless, despite the immaturity of the neonate, there was evidence that synthesis of DHA was occurring. However, by 7 years, no associations were observed with the maternal genotype. This suggested that the childrens FA levels were related only to their own metabolism with no apparent lasting influences of the in utero environment.