Neurofunctional correlates of theory of mind deficits in schizophrenia.
Neurofunctional correlates of theory of mind deficits in schizophrenia.
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DOI：
10.2174/1568026611212210002
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发表时间：
2012
影响因子：
3.4
通讯作者：
M. Bosia;R. Riccaboni;S. Poletti
中科院分区：
文献类型：
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作者：
M. Bosia;R. Riccaboni;S. Poletti
心智理论，即理解他人潜在心理状态和意图的能力，代表了社会认知的一个相关方面，对在社会世界中互动的能力有很大影响。在过去的几十年里，这种人类的能力一直是神经科学研究的焦点之一，来自神经成像研究的数据使我们能够确定一个心智理论网络，并制定一个神经生物学模型。同时进行的神经精神病学研究表明，心理理论在几种情况下受到不同程度的损害，其中包括精神分裂症，这是一种以功能和社会残疾为特征的疾病。本文讨论了精神分裂症患者心理理论缺陷的神经功能相关问题，回顾了过去十年来精神分裂症患者与健康对照者的功能影像学研究。在已知与社会认知密切相关的区域，如内侧前额叶皮层、颞上沟周围的颞叶皮层、颞顶交界处和扣带皮层，观察到患者和对照组之间的血流动力学反应存在一些差异。结果是有希望的，但它们仍然是异质的。报告的差异可能取决于心理理论本身的构建、技术方面和精神病理/生理病理机制等因素，需要在未来的研究中进一步解决。
Theory of Mind, the ability to understand the potential mental states and intentions of others, represents a relevant aspect of social cognition, with high impact on the capacity to interact within the social world. This very human ability has been one of the focuses of neuroscience research in the past decades and data from neuroimaging studies allowed to identify a Theory of Mind network and to formulate a neurobiological model. Concurrent neuropsychiatric studies showed that Theory of Mind is differently impaired in several conditions, among these, in schizophrenia, a disease characterized by functional and social disability. This paper addresses the issue of neurofunctional correlates of Theory of Mind deficits in schizophrenia, reviewing functional imaging studies of the past ten years comparing schizophrenia patients to healthy controls. Several differences in hemodynamic response between patients and controls were observed in the areas known to be critically involved in social cognition, such as the medial prefrontal cortex, temporal cortex surrounding superior temporal sulcus and temporo-parietal junction and cingulate cortex. Results are promising, however they are still heterogeneous. The reported variability could depend on factors related to the construct of Theory of Mind itself, technical aspects and psychopathological/physiopathological mechanisms and needs to be further addressed by future studies.