A small-scale robotic manipulandum for motor training in stroke rats
A small-scale robotic manipulandum for motor training in stroke rats
复制标题
用于中风大鼠运动训练的小型机器人操作器
DOI：
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
R. Gassert
中科院分区：
文献类型：
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作者：
B. Vigaru;O. Lambercy;Lina Graber;R. Fluit;Pascal Wespe;M. Schubring;A. Luft;R. Gassert
对感觉运动学习和执行的研究和表征是脑卒中后最佳康复治疗设计的关键目标。通过提供新的工具来研究感觉运动学习和客观地评估恢复，机器人辅助技术开辟了神经康复研究的新领域，旨在补充当前的临床策略。然而，人体研究受到复杂的后勤、异质性患者群体和高脱落率的限制。大鼠模型可以提供一种替代品，以探索这些过程的机制，在人类更大，更同质的人口。本文描述了一种三自由度机器人操作器的开发和评估，以训练和评估大鼠中风前后精确的前肢运动。根据与大鼠运动学和动力学相互作用的要求，提出了机械设计。机器人的表征表现出紧凑，低摩擦装置，具有足够的带宽适合与啮齿动物的运动训练研究。该机械手与现有的啮齿动物实验训练环境相结合，目前正在进行第一项研究。
The investigation and characterization of sensori-motor learning and execution represents a key objective for the design of optimal rehabilitation therapies following stroke. By supplying new tools to investigate sensorimotor learning and objectively assess recovery, robot assisted techniques have opened new lines of research in neurorehabilitation aiming to complement current clinical strategies. Human studies, however, are limited by the complex logistics, heterogeneous patient populations and large dropout rates. Rat models may provide a substitute to explore the mechanisms underlying these processes in humans with larger and more homogeneous populations. This paper describes the development and evaluation of a three-degrees-of-freedom robotic manipulandum to train and assess precision forelimb movement in rats before and after stroke. The mechanical design is presented based on the requirements of interaction with rat kinematics and kinetics. The characterization of the robot exhibits a compact, low friction device, with a sufficient bandwidth suitable for motor training studies with rodents. The manipulandum was integrated with an existing training environment for rodent experiments and a first study is currently underway.
DOI：
10.1056/nejmoa0911341
发表时间：
2010-05-13
期刊：
The New England journal of medicine
影响因子：
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作者：
Lo AC;Guarino PD;Richards LG;Haselkorn JK;Wittenberg GF;Federman DG;Ringer RJ;Wagner TH;Krebs HI;Volpe BT;Bever CT Jr;Bravata DM;Duncan PW;Corn BH;Maffucci AD;Nadeau SE;Conroy SS;Powell JM;Huang GD;Peduzzi P
通讯作者：
Peduzzi P