CYTOSAMINOMYCINS, NEW ANTICOCCIDIAL AGENTS PRODUCED BY STREPTOMYCES SP KO-8119 .2. STRUCTURE ELUCIDATION OF CYTOSAMINOMYCIN-A, CYTOSAMINOMYCIN-B, CYTOSAMINOMYCIN-C AND CYTOSAMINOMYCIN-D
CYTOSAMINOMYCINS, NEW ANTICOCCIDIAL AGENTS PRODUCED BY STREPTOMYCES SP KO-8119 .2. STRUCTURE ELUCIDATION OF CYTOSAMINOMYCIN-A, CYTOSAMINOMYCIN-B, CYTOSAMINOMYCIN-C AND CYTOSAMINOMYCIN-D
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DOI：
10.7164/antibiotics.47.782
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发表时间：
1994-07-01
影响因子：
3.3
通讯作者：
OMURA, S
中科院分区：
文献类型：
--
作者：
SHIOMI, K;HANEDA, K;OMURA, S
用核磁共振方法鉴定了新型抗球虫抗生素胞胺霉素A、B、C和D的结构。胞胺霉素是与奥昔卡西丁相关的核苷类抗生素。它们与胞嘧啶残基键合的羧酸部分不同于奥昔卡西丁。胞胺霉素A、B、C和D中所含的羧酸分别为（E）-3-（甲硫基）丙烯酸、4-甲氨基苯甲酸、3-甲基巴豆酸和惕各酸。
Structures of novel anticoccidial antibiotics, cytosaminomycins A, B, C and D, were elucidated by NMR studies. Cytosaminomycins were shown to be nucleoside antibiotics related to oxyplicacetin. Their carboxylic acid moieties bonded to the cytosine residue were different from that of oxyplicacetin. The carboxylic acids contained in cytosaminomycins A, B, C and D were (E)-3-(methylthio)acrylic acid, 4-methylaminobenzoic acid, 3-methylcrotonic acid, and tiglic acid, respectively.