α-Amidobenzylation of Aryl and Alkenyl Halides via Palladium-catalyzed Suzuki-Miyaura Coupling with α-(Acylamino)benzylboronic Esters
α-Amidobenzylation of Aryl and Alkenyl Halides via Palladium-catalyzed Suzuki-Miyaura Coupling with α-(Acylamino)benzylboronic Esters
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DOI：
10.1246/cl.2009.664
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发表时间：
2009-07-05
影响因子：
1.6
通讯作者：
Suginome, Michinori
中科院分区：
文献类型：
--
作者：
Ohmura, Toshimichi;Awano, Tomotsugu;Suginome, Michinori
在Pd/P（t-Bu）（3）催化剂上，以KF和水为溶剂，在1，4-二氧六环中进行了α-（乙酰氨基）苄基硼酸酯与卤代芳基和卤代烯基的Suzuki-Miyaura偶联反应，高产率地得到了α-取代苄胺。
The Suzuki-Miyaura coupling of alpha-(acetylatnino)benzyl-boronic esters with aryl and alkenyl halides has been achieved using a Pd/P(t-Bu)(3) catalyst with KF and H2O in 1,4-dioxane, giving a-substituted benzylamines in high yields.