Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib
Suppressed bone turnover by long-term bisphosphonate treatment accumulates microdamage but maintains intrinsic material properties in cortical bone of dog rib
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DOI：
10.1359/jbmr.040126
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发表时间：
2004-06-01
影响因子：
6.2
通讯作者：
Norimatsu, H
中科院分区：
文献类型：
--
作者：
Komatsubara, S;Mori, S;Norimatsu, H
研究了双膦酸盐对狗肋骨皮质骨长期抑制骨重塑的影响。尽管微损伤不断累积，但 BMD 却在不增加皮质骨面积的情况下增加。因此，材料的固有特性并未降低。
Effects of long-term suppression of bone remodeling by bisphosphonate were investigated in cortical bone of dog rib. Although microdamage was accumulated, BMD was increased without increasing cortical bone area. Consequently, the intrinsic material properties were not reduced.