Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review.
Adult stem cells and tissue engineering strategies for salivary gland regeneration: a review.
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DOI：
10.1186/2055-7124-18-9
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发表时间：
2014
影响因子：
11.3
通讯作者：
Jun HW
中科院分区：
文献类型：
--
作者：
Yoo C;Vines JB;Alexander G;Murdock K;Hwang P;Jun HW
唾液是由唾液腺产生的重要化合物，并执行许多功能。唾液分泌减少（口干综合征）是一种有害的疾病，通常由头颈癌患者的放射治疗引起，干燥综合征，或作为某些药物的副作用。唾液分泌不足对患者的说话、咀嚼和吞咽产生负面影响，大大降低了他们的生活质量。目前对这种病理学的治疗包括改变生活方式，合成唾液补充剂，以及利用唾液腺兴奋剂和促涎剂。然而，这些治疗中的许多治疗并没有解决根本问题，而其他治疗则充斥着许多副作用。为了解决与当前治疗方式相关的缺点，许多团体已经将注意力转移到利用组织工程和再生医学方法上。组织工程是将生命科学和材料工程应用于开发能够模仿其在体内的天然类似物的结构和功能的组织替代物。组织工程器官替代品开发背后的一般基本策略是利用细胞、生物材料和生物化学线索的组合，旨在重建自然器官环境。本文综述了目前涎腺组织工程的生物工程方法和用于此目的的成体干细胞来源。此外，未来的考虑方面的唾液腺组织工程策略进行了讨论。
Saliva is an important compound produced by the salivary glands and performs numerous functions. Hyposalivation (dry mouth syndrome) is a deleterious condition often resulting from radiotherapy for patients with head and neck cancer, Sjogren’s Syndrome, or as a side effect of certain medications. Hyposalivation negatively affects speaking, mastication, and swallowing in afflicted patients, greatly reducing their quality of life. Current treatments for this pathology include modifying lifestyle, synthetic saliva supplementation, and the utilization of salivary gland stimulants and sialagogues. However, many of these treatments do not address the underlying issues and others are pervaded by numerous side effects. In order to address the shortcomings related to current treatment modalities, many groups have diverted their attention to utilizing tissue engineering and regenerative medicine approaches. Tissue engineering is defined as the application of life sciences and materials engineering toward the development of tissue substitutes that are capable of mimicking the structure and function of their natural analogues within the body. The general underlying strategy behind the development of tissue engineered organ substitutes is the utilization of a combination of cells, biomaterials, and biochemical cues intended to recreate the natural organ environment. The purpose of this review is to highlight current bioengineering approaches for salivary gland tissue engineering and the adult stem cell sources used for this purpose. Additionally, future considerations in regard to salivary gland tissue engineering strategies are discussed.